Metagenomics to Metabolomics: Integrating Genomic Insights for Mulberry Crop Protection and Enhancement

ABSTRACT Indian Mulberry ( Morus indica ) is vital in sericulture, with their leaves serving as the primary food source for silkworms. The soil microbiome surrounding mulberry trees plays a pivotal role in nutrient cycling and ecosystem functioning. This study utilizes metagenomic analysis to explore the taxonomic diversity and functional potential of microbial communities in mulberry soil, particularly focusing on the rhizosphere. Key bacterial species such as Pseudomonas, Frankia, Azosipirulum are identified, highlighting their importance in mulberry health and disease dynamics. The abundance distribution of these bacterial populations reveals significant trends, offering insights into mulberry agroecosystem microbial ecology. Understanding garden soil-derived microbial consortia provides a foundation for exploring their role in nutrient cycling and plant health. The study reveals the intricate web of interactions between mulberry and their surrounding soil microbiota and identification of metabolites. Leveraging high-throughput sequencing and bioinformatics, the research identifies potential metabolites as biofertilizers and biopesticides, aiming to improve agricultural sustainability. The findings underscore the critical role of soil microbes in maintaining soil fertility, supporting plant health, and enhancing ecosystem resilience. Despite limitations and gaps, the study contributes to advancing eco-friendly agricultural practices and promoting soil health in mulberry cultivation. Ultimately, the research transcends the laboratory, resonating with stakeholders as it unravels the genetic blueprints of soil life and sows’ seeds of sustainable progress.