Virtual Screening of Kaempferia galanga L. Bioactive Compounds as HPV-16 Antiviral Mechanism Through E6 Inhibitor Activity

Human papillomavirus (HPV) infection is caused by a virus with a type of DNA genetic material from the Papillomaviridae family, about 90% of HPV infections have no definite symptoms. HPV infection is spread through sexual intercourse, multiple sexual partners, anal sex, and from mother to child during pregnancy. HPV has oncoproteins E6 & E7 which affect the ability to trigger cancer cases. The role of E6 is very crucial and is able to cause cells to lose homeostasis in the cell cycle and transform into cancer, this shows that E6 has the potential to be a binding target for HPV drug candidate compounds. Kaempferia galanga L. is used as a cooking spice in Indonesia and known as kencur, this plant is often used by Javanese and Balinese people to make jamoe. The potential of Kaempferia galanga L. as an antiviral only has little scientific evidence as previously done, the plant has high protease inhibitory activity of HIV-1 and HCV viruses. This study aims to identify chemical compounds from Kaempferia galanga L. which have potential as HPV antivirals through inhibition of E6 activity. Chemical compounds from Kaempferia galanga L. are predicted to be antiviral candidates through the activity of Ethyl cinnamate and γ-Cadinene with an E6 inhibition mechanism in the Val69 & Leu57 domains, the results of this study must be further analyzed through a wetlab approach to strengthen scientific evidence.