Revealing of Antiinflamatory Agent from Zingiber officinale var. Roscoe via IKK-B Inhibitor Mechanism through In Silico Simulation

Inflammation is a response to the immune system from attack by infectious agents. Its condition triggered by a phase of dilatation in the blood flow and increased membrane permeability in the area of ​​infection. The results of in vitro research showed that compounds from Zingiber officinale var. Roscoe extract could trigger a decrease in NF-κB protein activity and pro-inflammatory cytokine production. NF-κB activity is influenced by the IKK-B enzyme for the phosphorylation of IκBα and NF-κB complexes, phosphorylation triggers IκBα dissociation and releases NF-κB to trigger proinflammatory gene expression. Extract from the rhizome of Zingiber officinale var. Roscoe can prevent and treat inflammation in the human body, this treatment is classified as an alternative according to previous research. This study aims to identify the anti-inflammatory potential of Zingiber officinale var Roscoe through the mechanism of inhibition of IKKB enzyme activity through bioinformatics simulation. Zingiber officinale var. Roscoe is predicted to act as an anti-inflammatory agent through 6-shogaol with a mechanism of IKK-B phosphorylation activity inhibition at Ser177 and Ser181 residues, 6-shogaol is predicted to act as a drug-like molecule, the anti-inflammatory potential of Zingiber officinale var. Roscoe must undergo further analysis to provide strong scientific evidence.