Comparison of Insulin Resistance and Overian Volume in Patients with Polycystic Ovary Syndrome with and without Hashimoto

Abstract Objective: In this study, our aim was to divide the patients diagnosed with polycystic ovary syndrome (PCOS) and Hashimoto's thyroiditis (HT) into subgroups according to different clinical and laboratory findings. It is to investigate whether it will exacerbate it. Material and Methods: 46 PCOS patients and 46 PCOS patients diagnosed with HT were included in this study. A detailed medical history was taken from all participants. Polycystic ovary image was evaluated as below or above 10 ml and antral follicles were counted by transvaginal ultrasound. Insulin resistance of the patients was evaluated according to the fasting insulin (HOMA) index. Results: Insulin resistance was found to be associated with fasting insulin, HOMA index, body mass index and right ovarian volume in patients diagnosed with PCOS. Among the patients diagnosed with PCOS+HT, insulin resistance was found to be significantly correlated with fasting insulin, HOMA index, (BMI), (SHBG) and left ovarian volume. An increase in right ovarian volume was found in 37.5% of patients with PCOS without insulin resistance and in 76.3% of patients with insulin resistance. An increase in left ovarian volume was found in 35.7% of patients without insulin resistance diagnosed with PCOS+HT and in 68.8% of patients with insulin resistance. Conclusions: This study shows that in order to predict insulin resistance that causes long-term metabolic diseases, ovarian volume should be evaluated in every PCOS patient and all PCOS patients with increased ovarian volume should be investigated for insulin resistance. In addition, it has been observed that insulin resistance affects left ovarian volume in patients with PCOS+HT, while insulin resistance affects the volume of the right ovary more in patients with PCOS. At least one ovary has been found to be affected by long-term metabolic diseases.