Linking Brain Reserve to Glymphatic system Function in Mild Cognitive Impairment: Evidenced by Choroid Plexus Volume and DTI-ALPS

Motivation: Mild cognitive impairment (MCI) patients are often accompanied with gray matter (GM) atrophy and glymphatic impairment, which are associated with cognition Goal(s): To explored how glymphatic function is associated with cortical atrophy and cognitive decline in MCI Approach: We used DTI-ALPS and choroid plexus volume to reflect glymphatic markers. The relationships between glymphatic markers and GM volume and cognition were investigated Results: Our findings revealed that glymphatic markers were significantly lower in MCI, and were associated with GM atrophy and cognition. Impact: Our findings highlight that MCI patients exhibited decreased glymphatic activity compared to NCs, and glymphatic activity could be used to evaluate brain reserve in MCI, which is further related to cognitive impairment