THE CORRELATION OF THE SERUM C-REACTIVE PROTEIN LEVEL WITH THE C-REACTIVE PROTEIN GENE T-757C POLYMORPHISM AND RISK OF ACUTE MYOCARDIAL INFARCTION

Objectives To explore the association of the serum C-reactive protein (CRP) leve with the CRP gene T-757C polymorphism and risk of acute myocardial infarction (AMI) in Chinese Han population of Sunan region. Methods The CRP gene T-757C polymorphism was genotyped by polymerase reaction restriction-fragment length polymorphism analysis, and the serum CRP level was measured by ELISA in 213 AMI patients (AMI group) and 173 subjects without coronary heart disease (CHD) (control group). Results In Chinese Han population of Sunan region, there were CRP gene T-757C polymorphisms in patients with AMI and in subjects without CHD. The serum CRP level in AMI patients (5.985/6.527 µg/ml) was significantly higher than those in subjects without CHD (3.262/1.356 µg/ml) (p<0.01) and multivariate logistic regression analysis showed that the serum CRP leve was a independent risk factor of AMI [OR (95% CI)=2.048 (1.234–3.401), p<0.01]; In AMI patients, no significant differences were found in the serum CRP level among any genotype (CC, TC or TT) of the CRP gene T-757C (4.069/2.493 pg/ml vs 5.745/6.321 pg/ml vs 6.127/6.629 pg/ml), and there also were no significant differences in the serum CRP level among any genotypes in this locus within the same gender and age (p>0.05). Conclusions The elevated serum CRP level is an independent risk factor of AMI, but not influenced by CRP gene T-757C polymorphism in Chinese Han population of Sunan region.