Abstract IA010: Bioengineering cell-based therapeutics

Abstract Cell-based therapeutics are an emerging modality that can potentially treat many currently intractable diseases through uniquely powerful modes of action. Our group is innovating new biomaterials and cellular constructs for medicine and biology by combining chemical biology, cellular engineering, and multi-scale fabrication. We have pioneered innovative approaches to synthesizing and in vivo screening of large libraries of biomaterial formulations for tailored applications in immunology and medicine. In my talk, I will describe our advances in discovering immunomodulatory biomaterials that can interact appropriately with the host immune system for localized immunomodulation. I will highlight our efforts to develop “cytokine factories” locally activating the innate and adaptive immune response to generate systemic immunotherapy and eradicate metastatic cancer. This approach has advanced to phase I/II human clinical trials for treating recurrent, refractory ovarian cancer. Citation Format: Omid Veiseh. Bioengineering cell-based therapeutics [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Optimizing Therapeutic Efficacy and Tolerability through Cancer Chemistry; 2024 Dec 9-11; Toronto, Ontario, Canada. Philadelphia (PA): AACR; Mol Cancer Ther 2024;23(12_Suppl):Abstract nr IA010.