Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
FORMULATION AND EVALUATION OF TAFLUPROST OPHTHALMIC SOLUTION
View through CrossRef
The aim of the present study was to formulate, develop and evaluate ophthalmic solution containing Tafluprost. The selected prostaglandin analogue belongs to BCS - II. So to increase the solubility of the Tafluprost in WFI Beta Cyclodextrin was used by performing various trials variables of the experiments procedure Stirring time and speed were optimized to enhance the solubility. From the experimental procedure with different trails 20mg/mL of Cyclodextrins was fixed for the optimized formula. The product were characterized for appearance, physical state, colour and odour of the drug characteristics. The prepared formulations were evaluated for pH, osmolality and assay and found to be in acceptable ranges. Stability study was carried out for optimized formulation at 40°C±2°C /NMT 25%RH and 30°C ±2°C/ 65%±5% RH for 3 months, were evaluated for pH ,osmolality ,assay found to be within acceptable limits. Finally it can be concluded that the in house product Tafluprost ophthalmic solution was met with in the specification.
Society of Pharmaceutical Tecnocrats
Title: FORMULATION AND EVALUATION OF TAFLUPROST OPHTHALMIC SOLUTION
Description:
The aim of the present study was to formulate, develop and evaluate ophthalmic solution containing Tafluprost.
The selected prostaglandin analogue belongs to BCS - II.
So to increase the solubility of the Tafluprost in WFI Beta Cyclodextrin was used by performing various trials variables of the experiments procedure Stirring time and speed were optimized to enhance the solubility.
From the experimental procedure with different trails 20mg/mL of Cyclodextrins was fixed for the optimized formula.
The product were characterized for appearance, physical state, colour and odour of the drug characteristics.
The prepared formulations were evaluated for pH, osmolality and assay and found to be in acceptable ranges.
Stability study was carried out for optimized formulation at 40°C±2°C /NMT 25%RH and 30°C ±2°C/ 65%±5% RH for 3 months, were evaluated for pH ,osmolality ,assay found to be within acceptable limits.
Finally it can be concluded that the in house product Tafluprost ophthalmic solution was met with in the specification.
Related Results
The experience with the application of Azidrop in the ophthalmological practice
The experience with the application of Azidrop in the ophthalmological practice
Introduction. The infectious inflammatory diseases of the eyes are characterized by the high prevalence and the potential risk of impairment of visual acuity. Background. It is wid...
Oxymetazoline hydrochloride ophthalmic solution, 0.1%, boosts the effects of botulinum toxin on blepharospasm: a case series
Oxymetazoline hydrochloride ophthalmic solution, 0.1%, boosts the effects of botulinum toxin on blepharospasm: a case series
Abstract
Background
Oxymetazoline hydrochloride ophthalmic solution (0.1%) is a medication used to treat blepharoptosis. Patients who suffer from bl...
Non-Recommended Publishing Lists: Strategies for Detecting Deceitful Journals
Non-Recommended Publishing Lists: Strategies for Detecting Deceitful Journals
Abstract
The rapid growth of open access publishing (OAP) has significantly improved the accessibility and dissemination of scientific knowledge. However, this expansion has also c...
Treatment Trends in Dry Eye Disease and Factors Associated with Ophthalmic Follow-up Discontinuation in Japan
Treatment Trends in Dry Eye Disease and Factors Associated with Ophthalmic Follow-up Discontinuation in Japan
Despite the importance of dry eye disease (DED) treatment, the rate of DED treatment discontinuation, especially discontinuation of ophthalmic follow-up, remains unknown. This stud...
ASP Formulation Development Journey, Optimisation and Validation for Mangala Field
ASP Formulation Development Journey, Optimisation and Validation for Mangala Field
Abstract
Mangala is a large low salinity, high quality fluvial oil field reservoir in India with STOIIP of over one billion barrels of waxy and moderately viscous cr...
Selection of Injectable Drug Product Composition using Machine Learning Models (Preprint)
Selection of Injectable Drug Product Composition using Machine Learning Models (Preprint)
BACKGROUND
As of July 2020, a Web of Science search of “machine learning (ML)” nested within the search of “pharmacokinetics or pharmacodynamics” yielded over 100...
Procedure for Western blot v1
Procedure for Western blot v1
Goal: This document has the objective of standardizing the protocol for Western blot. This technique allows the detection of specific proteins separated on polyacrylamide gel and t...
FREQUENCY OF DIFFERENT OPHTHALMIC INJURIES IN PATIENTS WITH ZYGOMATICOMAXILLARY COMPLEX FRACTURE
FREQUENCY OF DIFFERENT OPHTHALMIC INJURIES IN PATIENTS WITH ZYGOMATICOMAXILLARY COMPLEX FRACTURE
Background: Zygomaticomaxillary complex (ZMC) fractures are common midfacial injuries due to the prominent position of the zygoma and its close anatomical relationship with the orb...