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Epigenetic regulation of miR-218 and its host gene, SLIT2 in breast cancer
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Abstract
Numerous studies have shown that microRNAs are deregulated in various types of cancer. Although miR-218 aberrant expression has been documented in various cancers, the epigenetic regulation of miR-218 is unclear in breast cancer. Our results demonstrate that treatment of breast cancer cells with demethylating agent, 5-azacytidine, resulted in increased expression of miR-218 and its host gene slit-2, suggesting that they are epigenetically regulated in breast cancer. The ectopic expression of miR-218 sensitize breast cancer cell to doxorubicin treatment. The results suggest that miR-218 is epigenetically regulated along with its host gene and function as a tumor suppressor in breast cancer. miR-218 and SLIT2 may have potential therapeutic value in combination with demethylating drug in breast cancer patients.
Title: Epigenetic regulation of miR-218 and its host gene, SLIT2 in breast cancer
Description:
Abstract
Numerous studies have shown that microRNAs are deregulated in various types of cancer.
Although miR-218 aberrant expression has been documented in various cancers, the epigenetic regulation of miR-218 is unclear in breast cancer.
Our results demonstrate that treatment of breast cancer cells with demethylating agent, 5-azacytidine, resulted in increased expression of miR-218 and its host gene slit-2, suggesting that they are epigenetically regulated in breast cancer.
The ectopic expression of miR-218 sensitize breast cancer cell to doxorubicin treatment.
The results suggest that miR-218 is epigenetically regulated along with its host gene and function as a tumor suppressor in breast cancer.
miR-218 and SLIT2 may have potential therapeutic value in combination with demethylating drug in breast cancer patients.
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