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Characterization of the nadR locus in Escherichia coli
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The biosynthesis of nicotinamide adenine dinucleotide (NAD) is under the genetic control of the nadR+ locus. The nadR+ allele is dominant to the nadR allele in transheterogenotes, indicating that the regulation is of the positive type. Mutants of the nadR type are unable to synthesize quinolinic acid; however, they do retain the ability to convert quinolinic acid into NAD and to recycle this NAD through the pyridine nucleotide cycle. Thus, the nadR+ locus regulates only genes involved in the biosynthesis of quinolinic acid.
Title: Characterization of the nadR locus in Escherichia coli
Description:
The biosynthesis of nicotinamide adenine dinucleotide (NAD) is under the genetic control of the nadR+ locus.
The nadR+ allele is dominant to the nadR allele in transheterogenotes, indicating that the regulation is of the positive type.
Mutants of the nadR type are unable to synthesize quinolinic acid; however, they do retain the ability to convert quinolinic acid into NAD and to recycle this NAD through the pyridine nucleotide cycle.
Thus, the nadR+ locus regulates only genes involved in the biosynthesis of quinolinic acid.
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