Formulation and In-vitro evaluation of mometasone furoate mucoadhesive microsphere for pulmonary drug delivery

The purpose of the study was to develop and evaluate mucoadhesive microspheres of Mometasone for pulmonary drug delivery system having prolonged residence time and sustained drug release. Microspheres were prepared by emulsification solvent evaporation technique using HPMC, carbopol as polymers in varying ratios. The microspheres were evaluated for its percentage yield, drug entrapment efficiency, particle size and shape, In vitro mucoadhesion study and In vitro drug release studies. The FTIR studies revealed no chemical interaction between the drug molecule and polymers and found that drug was compatible with used polymer. The mucoadhesive microspheres showed particle size, drug entrapment efficiency and yield in the ranges of 148 - 164μm, 68.0 - 85.0% and 67.52 - 87.25% respectively. In vitro drug release and mucoadhesion study confirms that formulation F5 was the best formulation as it releases 81.8 % at the end of 12 hr. in controlled manner and percentage mucoadhesion of 75.2 % after 10 hr. This confirms the developed Mometasone mucoadhesive microspheres are promising for pulmonary drug delivery system.