Two-sample Mendelian randomization to analyze the association between depression and osteoarthritis risk

Abstract BACKGROUND: Clinical experience has shown that psychiatric disorders are likely to be risk factors for osteoarthritis, and the incidence of depression, as an important category of psychiatric disorders, has been increasing year by year, but the association between depression and osteoarthritis has not yet been established. , as an important category of psychiatric disorders, has been increasing year by year, but the association between depression and osteoarthritis has not been clearly investigated. OBJECTIVE: To select a dataset of depression and osteoarthritis from the GWAS database and explore the relationship between the two by Mendelian randomisation analysis. RESEARCH METHODS: A database of depression and osteoarthritis was selected to explore the relationship between depression and osteoarthritis using the inverse variance weighting (IVW) method of the Mendelian randomised random-effects model, and the results of the study were supplemented with the the inverse variance weighting (IVW) method of the Mendelian randomized random-effects model, and the results of the study were supplemented with the use of the MR-Egger method, among others. The results of the study were supplemented with the use of the MR-Egger method, among others. RESULTS AND CONCLUSION: IVW results found a causal association between depression and osteoarthritis and that depression is a risk factor for osteoarthritis.