Methods for the Continuous Chromatographic Separation of Substances

Among many versions of methods for the chromatographic separation of substances, to date, insufficient attention has been paid to their continuous separation. Among a few exceptions is a review by Maryutina and Spivakov published in 2001 [4]. Our paper deals with a more detailed consideration of the attempts made for the continuous chromatographic separation of substances and the assessment of the efficiency of the solutions found. The aim of this review was to draw more attention to this promising direction for solving two interrelated problems. First, to creating systems for the continuous analytical control of complex multicomponent samples of the composition changing with time, and, second, to solving preparative and technological problems of the separation of substances with similar chemical properties. In the first case, the method ensures studies of the dynamics of changes in the composition of complex multicomponent mixtures in studying fast chemical processes, and, when used for technological purposes, it opens up a possibility of the continuous chemical-analytical monitoring of their course from the standpoint of economic efficiency and safety. In the second case, methods of continuous chromatographic separation ensure an increase in the efficiency and productivity of obtaining valuable high-purity substances.