Effect of eosinophils on T-cells in differently active Brain tumors

Abstract Objective To investigate the effect of eosinophils on T-cells in various active Brain tumors. Methods By analyzing the SDY1637 CyTOF data in Immport database, we observed the differences in immune cell composition and the correlation between eosinophils and T-cells function in different tumor models by applying CyTOF technology, heatmap and clustering analysis, and t-SNE downscaling visualization. Results The proportion of eosinophils and effector/memory T-cells was higher in immunoreactive Brain tumors, there was spatial synergy between them, and eosinophils promoted T-cells activation and memory phenotype differentiation; regulatory T-cells and depleted T-cells dominated in immunoinert Brain tumors, and eosinophils deficiency led to T-cells depletion. After tumor resection, eosinophils rebounded and remodeled the immune microenvironment. Conclusion Eosinophils have a significant impact on T-cells function in different active Brain tumors, targeting eosinophils is expected to enhance anti-tumor immunity and provide a new direction for Brain tumors therapy, and the molecular mechanism of the interaction between the two remains to be further investigated.