Effects of Oral Isotretinoin in Women with Acne and Polycystic Ovary Syndrome Running Title: Effects of Oral Isotretinoin

Abstract Background: Oral isotretinoin is the unique treatment for cure or prolonged remission for moderate and severe acne, preventing psychosocial impact and scars. Aim: The aim of study was to detect the effects of oral isotretinoin in women with acne and Polycystic Ovary Syndrome. Subject and Methods: This was a prospective clinical study included 40 patient's diagnosed clinically in women with acne and polycystic ovary syndrome. Patients will be recruited from dermatology and gynecology outpatient clinic at Damietta faculty of medicine, Al-azhar University. Results: there was a statistically significant difference between baseline and after treatment acne score (Mean ± SD= 2.42 ± 0.844 vs 0.73 ± 0.452, P < 0.001). Also there was a statistically significant difference between baseline and after treatment global acne score (Mean ± SD= 11.58 ± 5.857 vs 1.65 ± 1.369, P < 0.001), Conclusion: solely isotretinoin treatment may be beneficial in patients with PCOS and acne who are not capable of using OCPs. Large-scale and well-balanced studies are required to understand the effect of isotretinoin in these patients.