Aspergillus oryzae-Fermented Broken Rice and Rice Bran Exhibited Anti-photoaging Effect on UVB-irradiated Human Fibroblasts

The current study evaluated the efficacy of Aspergillus oryzae-fermented broken rice (FBR) and rice bran (FRB) extracts in inhibiting photoaging in UVB-irradiated fibroblasts. The FBR and FRB extracts at 50 and 100 µg/mL markedly suppressed intracellular elastase activity and the FRB extract at 100 µg/mL significantly lowered the MMP-1 secretion in UVB-irradiated fibroblasts. Both FRB and FRB extracts also significantly downregulated the expression of MMP-1 and SFE genes in the UVB-irradiated fibroblasts. Furthermore, the substantial elevation of COL1A1 gene expression by FBR and FRB extracts at 50 µg/mL also indicated the potential of these extracts to enhance collagen type 1 synthesis. The present findings indicate that FBR and FRB extracts may potentially serve as functional components to mitigate skin damage caused by UVB radiation. However, further investigation is necessary to ascertain the precise anti-photoaging mechanism.