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Synthesis and Anticancer Activity of Some 1H-inden-1-one Substituted (Heteroaryl)Acetamide Derivatives
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Background:
The synthesis of 2-[3/4-((6-substituted-1-oxo-2,3-dihydro-1H-inden-2-
ylidene)methyl)phenoxy]-N-(heteroaryl)acetamide derivatives and the investigation of their anticancer
activity were studied.
Methods:
2-(3/4-Hydroxybenzylidene)-6-substituted-2,3-dihydro-1H-inden-1-ones were reacted with
suitable 2-chloroacetamides to give 2-[3/4-((6-substituted-1-oxo-2,3-dihydro-1H-inden-2-ylidene)
methyl)phenoxy]-N-(heteroaryl)acetamide derivatives.
Results:
The structure elucidation of the newly synthesised 16 compounds was performed by IR,
1H-NMR, mass spectroscopic data and elemental analyses. The anticancer screening was carried
out in National Cancer Institute (NCI), USA.
Conclusion:
Compound 3e (2-(3-((6-chloro-1-oxo-2,3-dihydro-1H-inden-2-ylidene)methyl)phenoxy)-
N-(thiazol-2-yl)acetamide), exhibited highest growth inhibition against the leukaemia (61.47%),
non-small cell lung cancer (79.31%) and breast cancer (62.82%) cell lines.
Title: Synthesis and Anticancer Activity of Some 1H-inden-1-one Substituted (Heteroaryl)Acetamide Derivatives
Description:
Background:
The synthesis of 2-[3/4-((6-substituted-1-oxo-2,3-dihydro-1H-inden-2-
ylidene)methyl)phenoxy]-N-(heteroaryl)acetamide derivatives and the investigation of their anticancer
activity were studied.
Methods:
2-(3/4-Hydroxybenzylidene)-6-substituted-2,3-dihydro-1H-inden-1-ones were reacted with
suitable 2-chloroacetamides to give 2-[3/4-((6-substituted-1-oxo-2,3-dihydro-1H-inden-2-ylidene)
methyl)phenoxy]-N-(heteroaryl)acetamide derivatives.
Results:
The structure elucidation of the newly synthesised 16 compounds was performed by IR,
1H-NMR, mass spectroscopic data and elemental analyses.
The anticancer screening was carried
out in National Cancer Institute (NCI), USA.
Conclusion:
Compound 3e (2-(3-((6-chloro-1-oxo-2,3-dihydro-1H-inden-2-ylidene)methyl)phenoxy)-
N-(thiazol-2-yl)acetamide), exhibited highest growth inhibition against the leukaemia (61.
47%),
non-small cell lung cancer (79.
31%) and breast cancer (62.
82%) cell lines.
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