Bi 2 S 3 /GO heterojunction with enhanced sonodynamic therapy for breast cancer treatment

Sonodynamic therapy (SDT) has shown great potential in tumor treatment, but some sonosensitizers exhibit rapid recombination of electron-hole pairs, resulting in limited therapeutic efficacy against tumors. In this study, a nanocomposite of bismuth sulfide (Bi2S3) and graphene oxide (GO) was synthesized via a simple hydrothermal method (Bi2S3/GO). The experimental results indicate that under ultrasound irradiation, Bi2S3/GO exhibits superior reactive oxygen species (ROS) generation capacity and can decompose hydrogen peroxide to enhance ROS production. Furthermore, the degradation rate of glutathione(GSH) increases when the composite material is exposed to US irradiation. In vitro antitumor experiments reveal that Bi2S3/GO efficiently and rapidly kills tumor cells under ultrasonic irradiation. This approach to enhancing SDT efficacy by increasing ROS generation and accelerating GSH depletion offers a novel strategy for tumor treatment.