Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
SURO-2/TMEM39 Facilitates Collagen Secretion through the Formation of Large COPII Vesicles
View through CrossRef
Abstract
Fibrosis of various tissues is a typical disease caused by excessive production and secretion of extracellular matrix. We used Caenorhabditis elegans to investigate the formation of large transport vesicles to understand collagen secretion, a critical factor in fibrosis formation. The suro-2 mutant displays obvious defects in collagen secretion and cuticle structure including a rupture phenotype in early adults. Transmission electron microscopy exhibited that the cuticle thickness of the suro-2 mutant was severely reduced. SURO-2/TMEM39 has 8 transmembrane domains and localizes in the endoplasmic reticulum (ER) membrane. SURO-2 interacts directly with NPP-20/Sec13, a component of the coat protein II (COPII) complex responsible for ER-to-Golgi transport. SURO-2 and NPP-20 localized at the same large puncta, a large COPII vesicle enough to accommodate collagens. We report here that SURO-2/TMEM39 is highly conserved among animal species and is a specialized regulator of bulky collagen secretion rather than general transport in C. elegans.
Research Square Platform LLC
Title: SURO-2/TMEM39 Facilitates Collagen Secretion through the Formation of Large COPII Vesicles
Description:
Abstract
Fibrosis of various tissues is a typical disease caused by excessive production and secretion of extracellular matrix.
We used Caenorhabditis elegans to investigate the formation of large transport vesicles to understand collagen secretion, a critical factor in fibrosis formation.
The suro-2 mutant displays obvious defects in collagen secretion and cuticle structure including a rupture phenotype in early adults.
Transmission electron microscopy exhibited that the cuticle thickness of the suro-2 mutant was severely reduced.
SURO-2/TMEM39 has 8 transmembrane domains and localizes in the endoplasmic reticulum (ER) membrane.
SURO-2 interacts directly with NPP-20/Sec13, a component of the coat protein II (COPII) complex responsible for ER-to-Golgi transport.
SURO-2 and NPP-20 localized at the same large puncta, a large COPII vesicle enough to accommodate collagens.
We report here that SURO-2/TMEM39 is highly conserved among animal species and is a specialized regulator of bulky collagen secretion rather than general transport in C.
elegans.
Related Results
Deciphering the Role of TGF-β1 in Altering Collagen I and Collagen III in the New Zealand Rabbit’s (Oryctolagus cuniculus) Urethral Wall in Urethral Stricture Development
Deciphering the Role of TGF-β1 in Altering Collagen I and Collagen III in the New Zealand Rabbit’s (Oryctolagus cuniculus) Urethral Wall in Urethral Stricture Development
Background: Presently, there's a lack of standardization in animal models used for studying urethral stricture. Transforming Growth Factor Beta 1 (TGF-β1) is known to regulate the ...
Human Insulin Vesicle Dynamics During Pulsatile Secretion
Human Insulin Vesicle Dynamics During Pulsatile Secretion
In healthy individuals, plasma insulin levels oscillate in both fasting and fed states. Numerous studies of isolated pancreata and pancreatic islets support the hypothesis that ins...
ER retention is imposed by COPII protein sorting and attenuated by 4-phenylbutyrate
ER retention is imposed by COPII protein sorting and attenuated by 4-phenylbutyrate
Native cargo proteins exit the endoplasmic reticulum (ER) in COPII-coated vesicles, whereas resident and misfolded proteins are substantially excluded from vesicles by a retention ...
Abstract 173: Adipocytes-derived collagen reorganization in microenvironment promotes breast cancer progression
Abstract 173: Adipocytes-derived collagen reorganization in microenvironment promotes breast cancer progression
Abstract
Purposes
Breast cancer cells recruit surrounding stromal cells, such as cancer-associated fibroblasts (CAFs), to reorganize collagen and prom...
Consideraţii clinico-epidemiologice în legătură cu ulcerul primar la copil – studiu retrospectiv pe 5 ani
Consideraţii clinico-epidemiologice în legătură cu ulcerul primar la copil – studiu retrospectiv pe 5 ani
Ulcerul peptic primar se menţine frecvent la copiii din ţările în curs de dezvoltare cu o incidenţă crescută a infecţiei cu H. pylori. Autorii au efectuat un studiu retrospectiv pe...
The Versatility of Collagen in Pharmacology: Targeting Collagen, Targeting with Collagen
The Versatility of Collagen in Pharmacology: Targeting Collagen, Targeting with Collagen
Collagen, a versatile family of proteins with 28 members and 44 genes, is pivotal in maintaining tissue integrity and function. It plays a crucial role in physiological processes l...
An alternative source of collagen for Muslim consumers: halal and environmental concerns
An alternative source of collagen for Muslim consumers: halal and environmental concerns
Purpose
The sources of collagens and gelatins are recently being questioned because it sourced from porcine or non-halal slaughtered animals. There are also concerns regarding the ...
(084) Analysis of BMP4 and GREMLIN as targets of SHH signaling and regulators of the collagen axis in the penis.
(084) Analysis of BMP4 and GREMLIN as targets of SHH signaling and regulators of the collagen axis in the penis.
Abstract
Introduction
Increased collagen deposition occurs in erectile dysfunction (ED) patients and animal models, and the unde...