A pan cancerous analysis of FNDC3B in human multiple tumors

Abstract More and more evidence indicated the relationship between FNDC3B and the invasion and metastasis in numerous types, However, there is no analysis of FNDC3B in various cancers yet. Therefore, in this study, we first explored the potential carcinogenic effects of FNDC3B in 33 types of tumors based on the TCGA and GEO datasets. FNDC3B is highly expressed in most cancers, and there is a significant correlation between the expression of FNDC3B and the prognosis of tumor patients. We observed increased phosphorylation levels of S208 in some tumors, such as lung adenocarcinoma, ovarian cancer, clear cell RCC or UCEC. In invasive breast cancer and head and neck squamous cell carcinoma, the expression of FNDC3B is correlated with CD8 + T-cell infiltration levels. In other tumors, such as colon adenocarcinoma, lung squamous cell carcinoma or rectum adenocarcinoma, cancer-related fibroblast infiltration is also observed. In addition, protein processing and RNA metabolism-related functions in endoplasmic reticulum participate in the functional mechanisms of FNDC3B. Our primary pan cancer study provides a comprehensive understanding of the carcinogenic role of FNDC3B in different tumors.