pdf Nestatin-1 Level as Potential Parameters in T2DM with and Without Osteoporosis

In osteoporosis (OP) disease, the strength of bones is decreased, and it is mostly correlated with the loss of bone tissues and destruction of bone micro structure, making the patients highly vulnerable to bone fracture and markedly decreases their life quality. This study aimed to assess the nestatin-1 level and other biochemical parameters in Iraqi t2dm with and without osteoporosis.  This study includes 90 volunteers; their information and history were divided to three groups with T2D with osteoporosis and without osteoporosis and control was taken by questionnaire. A highly significant elevation in the levels of FBS, HbA1C, TC, TG, LDL-C and vitamin D3 was found among study groups (T2D with osteoporosis, T2D without osteoporosis and controls), while HDL-C was highly significantly decreased among study groups (T2D with osteoporosis, T2D without osteoporosis and control).Also we have shown that there was a significant increase of calcium, phosphorus and alkaline phosphates among study groups (T2D with osteoporosis, T2D without osteoporosis and control). A highly significant decreased ofNestatin-1 level among study groups (T2D with osteoporosis, T2D without osteoporosis and the controls). It can be concluded that decreased Nestatin-1 level among T2DM with and without osteoporosis when compared with the controls may be a storing cause to insulin resistance in T2DM patients and may be considered as a biomarker for prediction of osteoporosis risks and as a therapeutic target for osteoporosis treatment.