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Links Between Repeated Sequences
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L1 and Alu elements are long and short interspersed
retrotransposable elements (LINEs and SINEs) in humans,
respectively. Proteins encoded in the autonomous L1 mediate
retrotransposition of the nonautonomous Alu and cellular
mRNAs. Alu is the only active SINE in the human genome
and is derived from 7SL RNA of signal recognition particle. In the
other eukaryotic genomes, various tRNA‐ and 5S rRNA‐derived SINEs
are found. Some of the tRNA‐ and 5S rRNA‐derived SINEs have
partner LINEs of which 3′ sequences are similar to those of the
SINEs. One of the tRNA‐derived SINEs is shown to be mobilized by
its partner LINE. Many copies of tRNA and 5S rRNA pseudogenes are
present in the human genome. These pseudogenes may have been
generated via the retrotransposition process using L1 proteins.
Although there are no sequence similarities between L1 and
Alu, L1 functionally links with Alu and even
cellular genes, impacting on our genome shaping.
Title: Links Between Repeated Sequences
Description:
L1 and Alu elements are long and short interspersed
retrotransposable elements (LINEs and SINEs) in humans,
respectively.
Proteins encoded in the autonomous L1 mediate
retrotransposition of the nonautonomous Alu and cellular
mRNAs.
Alu is the only active SINE in the human genome
and is derived from 7SL RNA of signal recognition particle.
In the
other eukaryotic genomes, various tRNA‐ and 5S rRNA‐derived SINEs
are found.
Some of the tRNA‐ and 5S rRNA‐derived SINEs have
partner LINEs of which 3′ sequences are similar to those of the
SINEs.
One of the tRNA‐derived SINEs is shown to be mobilized by
its partner LINE.
Many copies of tRNA and 5S rRNA pseudogenes are
present in the human genome.
These pseudogenes may have been
generated via the retrotransposition process using L1 proteins.
Although there are no sequence similarities between L1 and
Alu, L1 functionally links with Alu and even
cellular genes, impacting on our genome shaping.
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