Metrological and Visual Analysis of the Status of Hypotension in Septic Shock

Abstract Background:At present, there is a lot of research in the field of septic shock and hypotension, but there is no comprehensive analysis of the current situation, hot spots and frontiers in this field，and many researchers don't know where to start..Therefore，in this study, the research status, research hotspots and frontier trends of septic shock hypotension in the past 30 years were analyzed by knowledge graph, so as to provide a reference basis for further research.Methods: We collected the literature related to hypotension in septic shock in Web Of Science (WOS) from 1991 to 2020, and made a bibliometric analysis of the literature. At the same time, we Use Excel2019 and Adobe Illustrator CC2018 software to analyze the annual volume of articles and draw bar charts and VOSviewer software to draw the relevant maps of countries, authors and institutions to explore the cooperative relationship in this field and CiteSpace software to draw keyword co-occurrence map, cluster timeline map and emergence map of keywords, and analyze the frontiers and hotspots in this field.Results: A total of 1419 articles were obtained, of which the country with the largest number of articles was the United States, and the centrality was the highest. Professor Bellomo Rinaldo in Australia has published the largest number of articles, up to 29 articles, which plays an important role in this field. In the organization cooperation graph, Univ sao Paulo cooperates closely with other agencies and publishes a large number of articles. There are high-frequency keywords such as sepsis, septic shock and hypotensio, 11 clusters such as relative adrenal insufficiency, nitric oxide and thromboxane, and high-prominence keywords of endotoxin and tumor necrosis factor.Conclusion: In the past 30 years, the volume of articles in the field of hypotension in septic shock showed a steady upward trend. Institutions in North America, Australia and Europe have made outstanding contributions to this field, but the degree of inter-country and inter-agency cooperation is worrying. Three major author cooperation groups have been formed, with close ties within the group. In the future, international exchanges and cooperation can be strengthened and the degree of cooperation in this field can be improved. Drugs for the treatment of hypotension, molecular mechanisms including endotoxin and tumor necrosis factor, and physiological and pathological mechanisms of hypotension are the research hotspots and frontiers in recent years.