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Bilateral Internuclear Ophthalmoplegia: Multiple Sclerosis rather Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD)?
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Increasing knowledge about neuro-inflammatory conditions as lead to new challenges in establishing a diagnosis. Clinical distinctive features might help. We present a 34-year-old patient with bilateral internuclear ophthalmoplegia (bINO). Investigation was compatible with demyelinating central nervous system (CNS) disease.
Low-positive IgG myelin oligodendrocyte glycoprotein (MOG) antibodies were found. Rituximab was started and the patient has remained without further clinical or magnetic resonance imaging (MRI) activity. Acknowledging that bINO is a wellknown manifestation of multiple sclerosis (MS) but rarely reported among MOGAD patients its occurrence might help distinguish MS from MOGAD in an apparent overlap setting, favoring MS.
Title: Bilateral Internuclear Ophthalmoplegia: Multiple Sclerosis rather Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD)?
Description:
Increasing knowledge about neuro-inflammatory conditions as lead to new challenges in establishing a diagnosis.
Clinical distinctive features might help.
We present a 34-year-old patient with bilateral internuclear ophthalmoplegia (bINO).
Investigation was compatible with demyelinating central nervous system (CNS) disease.
Low-positive IgG myelin oligodendrocyte glycoprotein (MOG) antibodies were found.
Rituximab was started and the patient has remained without further clinical or magnetic resonance imaging (MRI) activity.
Acknowledging that bINO is a wellknown manifestation of multiple sclerosis (MS) but rarely reported among MOGAD patients its occurrence might help distinguish MS from MOGAD in an apparent overlap setting, favoring MS.
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