Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
A Retrospective Study on Adverse Drug Reactions of Anticancer Drugs in a Tertiary Care Hospital in Northeast India
View through CrossRef
Introduction: Anticancer drugs account to high susceptibility towards Adverse Drug Reactions (ADRs) due to their narrow therapeutic window and increased toxicity, which makes pharmacovigilance studies essential. Aim: To determine the nature and severity of ADRs in cancer patients based on the reports received from the Department of Radiation Oncology to the Pharmacovigilance centre of a tertiary care hospital. Materials and Methods: A retrospective, descriptive study was conducted in the Regional Institute of Medical Sciences (RIMS), Imphal, Manipur, India on the patients who developed ADRs due to anticancer drugs during the period from January 2018 to December 2020. These ADRs were assessed for causality using World Health Organisation- Uppsala Monitoring Centre (WHO-UMC) criteria. The data was analysed using Statistical Package for the Social Sciences (SPSS) version 21.0 and frequencies and percentages were determined for each variable. Results: A total of 913 ADRs were reported from 334 patients. Total 62.57% females developed ADRs and age group of 51-60 years (31.14%) were affected the most. Bronchogenic carcinoma (20.9%) was found to be the most common cancer and haematological system (31.11%) was mostly affected. Most common ADRs observed were alopecia (16.32%) followed by anorexia and anaemia. Carboplatin (23.21%) followed by Cisplatin, Paclitaxel, Docetaxel were the most common drugs causing different ADRs. On causality assessment, as per WHO-UMC criteria 67.25% ADRs were ‘probable’ and 32.75% were ‘possible’. Severity assessment using modified Hartwig and Siegel scale showed 56.41% ADRs as mild, 41.95% moderate and 1.64% severe reaction. Preventability assessment using Schumock-Thornton scale showed 44.69% ADRs were ‘not preventable’ whereas 41.62% ADRs were ‘definitely preventable’ and 13.69% were ‘probably preventable’. Conclusion: The use of anticancer drugs is associated with various adverse effects. However, early detection of the ADRs may help to modify the doses or the drug regimen to minimise the adverse effects.
Title: A Retrospective Study on Adverse Drug Reactions of Anticancer Drugs in a Tertiary Care Hospital in Northeast India
Description:
Introduction: Anticancer drugs account to high susceptibility towards Adverse Drug Reactions (ADRs) due to their narrow therapeutic window and increased toxicity, which makes pharmacovigilance studies essential.
Aim: To determine the nature and severity of ADRs in cancer patients based on the reports received from the Department of Radiation Oncology to the Pharmacovigilance centre of a tertiary care hospital.
Materials and Methods: A retrospective, descriptive study was conducted in the Regional Institute of Medical Sciences (RIMS), Imphal, Manipur, India on the patients who developed ADRs due to anticancer drugs during the period from January 2018 to December 2020.
These ADRs were assessed for causality using World Health Organisation- Uppsala Monitoring Centre (WHO-UMC) criteria.
The data was analysed using Statistical Package for the Social Sciences (SPSS) version 21.
0 and frequencies and percentages were determined for each variable.
Results: A total of 913 ADRs were reported from 334 patients.
Total 62.
57% females developed ADRs and age group of 51-60 years (31.
14%) were affected the most.
Bronchogenic carcinoma (20.
9%) was found to be the most common cancer and haematological system (31.
11%) was mostly affected.
Most common ADRs observed were alopecia (16.
32%) followed by anorexia and anaemia.
Carboplatin (23.
21%) followed by Cisplatin, Paclitaxel, Docetaxel were the most common drugs causing different ADRs.
On causality assessment, as per WHO-UMC criteria 67.
25% ADRs were ‘probable’ and 32.
75% were ‘possible’.
Severity assessment using modified Hartwig and Siegel scale showed 56.
41% ADRs as mild, 41.
95% moderate and 1.
64% severe reaction.
Preventability assessment using Schumock-Thornton scale showed 44.
69% ADRs were ‘not preventable’ whereas 41.
62% ADRs were ‘definitely preventable’ and 13.
69% were ‘probably preventable’.
Conclusion: The use of anticancer drugs is associated with various adverse effects.
However, early detection of the ADRs may help to modify the doses or the drug regimen to minimise the adverse effects.
Related Results
Evolution of Antimicrobial Resistance in Community vs. Hospital-Acquired Infections
Evolution of Antimicrobial Resistance in Community vs. Hospital-Acquired Infections
Abstract
Introduction
Hospitals are high-risk environments for infections. Despite the global recognition of these pathogens, few studies compare microorganisms from community-acqu...
Selection of Injectable Drug Product Composition using Machine Learning Models (Preprint)
Selection of Injectable Drug Product Composition using Machine Learning Models (Preprint)
BACKGROUND
As of July 2020, a Web of Science search of “machine learning (ML)” nested within the search of “pharmacokinetics or pharmacodynamics” yielded over 100...
Awareness of Adverse Drug Reactions and its Reporting among Third-year Undergraduate Medical Students
Awareness of Adverse Drug Reactions and its Reporting among Third-year Undergraduate Medical Students
Background: Drug is a double-edged sword. Though important, Adverse Drug Reactions under-reporting is real and is mainly due to lack of awareness. No published research has ever ev...
Studi Literatur Kasus Adverse Drug Reactions Dari Pengaruh Bahan Eksipien Obat
Studi Literatur Kasus Adverse Drug Reactions Dari Pengaruh Bahan Eksipien Obat
Abstract. Adverse Drug Reactions (ADRs) are generally triggered by active substances contained in the drugs used, but it is possible that these ADR events are caused and triggered ...
Current Perspectives on Cystic Echinococcosis: A Systematic Review
Current Perspectives on Cystic Echinococcosis: A Systematic Review
Abstract
Introduction: Hydatidosis, a zoonotic disease caused by the larval stage of Echinococcus granulosus, is a significant public health concern with notable economic impact. I...
ANALYSIS OF FACTORS INFLUENCING ADHERENCE TO ANTIRETROVIRAL MEDICATION (ARV) IN HIV/AIDS PATIENTS BASED ON INFORMATION, MOTIVATION, BEHAVIORAL SKILLS AT CUT MEUTIA GENERAL HOSPITAL
ANALYSIS OF FACTORS INFLUENCING ADHERENCE TO ANTIRETROVIRAL MEDICATION (ARV) IN HIV/AIDS PATIENTS BASED ON INFORMATION, MOTIVATION, BEHAVIORAL SKILLS AT CUT MEUTIA GENERAL HOSPITAL
HIV (Human Immunodeficiency Virus), included in the Retroviridae family, is a virus that causes AIDS (Acquired Immunodeficiency Syndrome), a syndrome caused by a decrease in the bo...
Analysis of adverse drug reaction reporting at Hue University of Medicine and Pharmacy Hospital
Analysis of adverse drug reaction reporting at Hue University of Medicine and Pharmacy Hospital
Background: In Pharmacovigilance, spontaneous reporting of adverse drug reactions is the most common method used in many countries around the world to detect and monitor adverse dr...
Health policies and programs facilitating access to high-cost anticancer drugs
Health policies and programs facilitating access to high-cost anticancer drugs
Access to anticancer drugs is limited mainly due to their high cost. To support policymakers in Thailand to develop policies and programs to facilitate better access to high-cost a...