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Natural killer cells immunosenescence
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Natural killer cells (NKs) are lymphocytes of the innate immune system
that quickly respond to viruses, infections, and tumors during their
short cell life cycle. However, it was recently found that NKs undergo
quantitative, distributional, structural, and functional phenotypic
changes during aging that suppress immune responses, which is known as
immunosenescence. The aging host environment, cytokine regulation,
cytomegalovirus status, and hypothalamic‒pituitary‒adrenal axis have
significant effects on NK function. Different lifestyle management
interventions modulate the number and cytotoxic activity of NKs, which
are essential for rebuilding the immune barrier against pathogens in
elderly individuals. Based on recent studies, we review the phenotypic
changes of and potential threats of NKs during aging and explore the
underlying mechanisms. By summarizing the effects of lifestyle
management on NKs and their application prospects, we aim to provide
evidence for enhancing immune system function against immune diseases in
elderly individuals.
Title: Natural killer cells immunosenescence
Description:
Natural killer cells (NKs) are lymphocytes of the innate immune system
that quickly respond to viruses, infections, and tumors during their
short cell life cycle.
However, it was recently found that NKs undergo
quantitative, distributional, structural, and functional phenotypic
changes during aging that suppress immune responses, which is known as
immunosenescence.
The aging host environment, cytokine regulation,
cytomegalovirus status, and hypothalamic‒pituitary‒adrenal axis have
significant effects on NK function.
Different lifestyle management
interventions modulate the number and cytotoxic activity of NKs, which
are essential for rebuilding the immune barrier against pathogens in
elderly individuals.
Based on recent studies, we review the phenotypic
changes of and potential threats of NKs during aging and explore the
underlying mechanisms.
By summarizing the effects of lifestyle
management on NKs and their application prospects, we aim to provide
evidence for enhancing immune system function against immune diseases in
elderly individuals.
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