Biogenic Amines in Gliomas: A Comprehensive Literature Review

Gliomas are primary brain tumors that are believed to originate from neuroglial cells or progenitor cells and are the most common neoplasms affecting the central nervous system (CNS). Gliomas can be categorized into two main groups based on the WHO classification system: low-grade gliomas and high-grade gliomas. Unfortunately, high-grade gliomas have a poor prognosis despite significant research efforts dedicated to discovering more effective treatments. Biogenic amines are organic compounds found in food, plants, and animals. They are produced through the chemical decarboxylation of amino acids. Interestingly, some biogenic amines are known for their toxic and carcinogenic properties. However, the full role of biogenic amines in gliomas has not been fully explored. In this review, we aim to investigate the known roles of biogenic amines in glioma development, diagnostics, and potential future treatment applications.