P22 Central and Peripheral Contributions to Submaximal Exercise Performance in Older Adults in the SouthAll and Brent REvisited (SABRE) Study

Abstract Background Functional capacity declines with age leading to disability and increased cost of health and social care. In older adults, factors that influence the ability to sustain sub-maximal exercise (a marker of functional capacity) are not well defined. We aimed to determine the contribution of cardiac function, skeletal muscle oxygen desaturation, extraction and oxidative capacity to sub-maximal exercise performance in a population-based sample of older adults. Methods Participants in the SABRE study undertook a 6-minute stepper test (6MST). Sub-maximal exercise performance was assessed as the highest achieved whole-body oxygen uptake (VO2) during the 6MST. Near Infrared Spectroscopy (NIRS) was used to locally assess skeletal muscle oxygen extraction, desaturation and maximum oxidative capacity. Echocardiography was used to measure cardiac function. Analysis was by multiple linear regression adjusted for confounders: age, sex, ethnicity, diabetes and obesity. Results 395 participants (73.0 ± 6.3 years old, male; n = 229) undertook the 6MST, skeletal muscle desaturation measurements and echocardiography. Skeletal muscle desaturation and cardiac output were independently associated with whole-body VO2 (standardized β: −0.20, p < 0.001 & 0.47, p < 0.001, respectively). Local skeletal muscle oxygen extraction was independently associated with whole-body VO2 (standardized β adjusted for confounders & cardiac output: 0.32, p < 0.001). Maximum oxidative capacity was not associated with VO2 (β (95% CI: 0.02 (−0.01, 0.04), p = 0.152). Conclusion Local oxygen extraction and desaturation in skeletal muscle are independent predictors of sub-maximal exercise performance in older adults. These associations persist with adjustment for cardiac output suggesting local capacity to extract oxygen could be a major limiting factor functional capacity in older adults.