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Parvoviruses

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This chapter discusses parvoviruses, which show a degree of dependence as they can replicate only in the presence of active DNA synthesis in rapidly dividing host cells or under the influence of another virus infection. Their genome of 5kb is small but larger than hepatitis B virus (3kb) and the same size as polyomaviruses, but their DNA is single-stranded and allows compact packaging. The chapter examines the complex relationship of the parvoviruses with the host, noting that there is only restricted ability to cultivate them in the laboratory and there are no animal models. Their wide circulation and self-limiting clinical course have led to a diminished appreciation of their clinical importance. The chapter highlights the two subfamilies of Parvoviridae: Parvovirinae, which infect vertebrates, and Densovirinae, which infect invertebrates.
Title: Parvoviruses
Description:
This chapter discusses parvoviruses, which show a degree of dependence as they can replicate only in the presence of active DNA synthesis in rapidly dividing host cells or under the influence of another virus infection.
Their genome of 5kb is small but larger than hepatitis B virus (3kb) and the same size as polyomaviruses, but their DNA is single-stranded and allows compact packaging.
The chapter examines the complex relationship of the parvoviruses with the host, noting that there is only restricted ability to cultivate them in the laboratory and there are no animal models.
Their wide circulation and self-limiting clinical course have led to a diminished appreciation of their clinical importance.
The chapter highlights the two subfamilies of Parvoviridae: Parvovirinae, which infect vertebrates, and Densovirinae, which infect invertebrates.

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