Javascript must be enabled to continue!
Sarcopenia As a Determinant Prognostic Factor After Surgery Among Patients with Colorectal Cancer
View through CrossRef
Introduction: Surgery for colorectal cancer (CRC) is not risk-free; therefore, preoperative evaluation must be done to predict and prevent surgical complications. Sarcopenia, a loss of muscle mass and function, was shown to be associated with surgical complications. Our study evaluates the effects of sarcopenia on short-term patient outcomes after CRC resection. Materials and Methods: Our retrospective study included patients with histologically proven CRC between 2018 and 2020 who underwent surgical resection. Skeletal muscle mass (cm2) was evaluated on a preoperative CT scan at the level of L3 vertebrae then standardized using stature (m2) to obtain the skeletal mass index (SMI) (cm2/m2). Patients received proper adjuvant care if needed and were followed up 90 days post surgery. Descriptive statistics were presented in percentage for categorical variables and in mean for continuous variables. Multivariate was made by linear regression. Results: 113 patients were included, and 15% were sarcopenic. A statistically non-significant association was found between sarcopenia and severe complications (grade III-IV) (23.53% in sarcopenic vs. 9.38% non-sarcopenic, p=0.02, multivariate p=0.675). Sarcopenia was not associated with anastomotic leakage, infectious complications, or ileus or intra-abdominal bleeding (p>0.05). In literature, some studies showed an association between sarcopenia and postoperative complications while others showed no relationship between the two. Most studies used SMI. Conclusion: A non-statistically significant association was found between sarcopenia and postoperative complications in CRC patients. Sarcopenia does not predict postoperative severe complications, anastomotic leakage, infectious complications, or ileus or intra-abdominal bleeding. Emergent surgeries and age >60 years were associated with more postoperative complications.
Title: Sarcopenia As a Determinant Prognostic Factor After Surgery Among Patients with Colorectal Cancer
Description:
Introduction: Surgery for colorectal cancer (CRC) is not risk-free; therefore, preoperative evaluation must be done to predict and prevent surgical complications.
Sarcopenia, a loss of muscle mass and function, was shown to be associated with surgical complications.
Our study evaluates the effects of sarcopenia on short-term patient outcomes after CRC resection.
Materials and Methods: Our retrospective study included patients with histologically proven CRC between 2018 and 2020 who underwent surgical resection.
Skeletal muscle mass (cm2) was evaluated on a preoperative CT scan at the level of L3 vertebrae then standardized using stature (m2) to obtain the skeletal mass index (SMI) (cm2/m2).
Patients received proper adjuvant care if needed and were followed up 90 days post surgery.
Descriptive statistics were presented in percentage for categorical variables and in mean for continuous variables.
Multivariate was made by linear regression.
Results: 113 patients were included, and 15% were sarcopenic.
A statistically non-significant association was found between sarcopenia and severe complications (grade III-IV) (23.
53% in sarcopenic vs.
9.
38% non-sarcopenic, p=0.
02, multivariate p=0.
675).
Sarcopenia was not associated with anastomotic leakage, infectious complications, or ileus or intra-abdominal bleeding (p>0.
05).
In literature, some studies showed an association between sarcopenia and postoperative complications while others showed no relationship between the two.
Most studies used SMI.
Conclusion: A non-statistically significant association was found between sarcopenia and postoperative complications in CRC patients.
Sarcopenia does not predict postoperative severe complications, anastomotic leakage, infectious complications, or ileus or intra-abdominal bleeding.
Emergent surgeries and age >60 years were associated with more postoperative complications.
Related Results
#986 Sarcopenia and chronic kidney disease among adults over 45 years old: findings from CHARLS
#986 Sarcopenia and chronic kidney disease among adults over 45 years old: findings from CHARLS
Abstract
Background and Aims
Little is known about the association between sarcopenia and chronic kidney disease (CKD) among Chi...
Abstract A13: Applied the proteomics characteristics to detect the inherited colorectal adenomas
Abstract A13: Applied the proteomics characteristics to detect the inherited colorectal adenomas
Abstract
Introduction: Current study found that about one-third of the incidence of colorectal cancer have genetic related. Hereditary nonpolyposis colorectal cancer...
Abstract 733: Relationship between pre-diagnostic biomarkers and sarcopenia in colorectal cancer patients
Abstract 733: Relationship between pre-diagnostic biomarkers and sarcopenia in colorectal cancer patients
Abstract
To gain further understanding of why some colorectal cancer patients develop sarcopenia (loss of skeletal muscle mass) we conducted a study of metabolic and...
Associations of body mass index and sarcopenia with screen-detected mild cognitive impairment in older adults in Colombia
Associations of body mass index and sarcopenia with screen-detected mild cognitive impairment in older adults in Colombia
Background and objectiveMore research is required to understand associations of body mass index (BMI) and sarcopenia with cognition, especially in Latin America. The objective of t...
Relationship between Sarcopenia in Abdomen CT Scan Results with C-Reactive Protein Level in Colorectal Cancer Patients at Dr. Soetomo General Academic Hospital Surabaya
Relationship between Sarcopenia in Abdomen CT Scan Results with C-Reactive Protein Level in Colorectal Cancer Patients at Dr. Soetomo General Academic Hospital Surabaya
Introduction: Colorectal cancer is the third most malignant and the fourth-largest cause of death in the world, one of which is caused by cachexia cancer. Sarcopenia is the main di...
Clinical Relations of Sarcopenia
Clinical Relations of Sarcopenia
Sarcopenia is one of geriatric syndromes, characterized by decreased muscle mass accompanied by decreased muscle strength and/or performance. It is more prevalent with increase in ...
The impact of sarcopenia on prognosis and fruquintinib efficacy in advanced colorectal cancer: a retrospective and mendelian randomization study
The impact of sarcopenia on prognosis and fruquintinib efficacy in advanced colorectal cancer: a retrospective and mendelian randomization study
BackgroundReportedly, sarcopenia is associated with prognosis in advanced colorectal cancer (CRC) patients and can lead to reduced efficacy of targeted therapy. However, studies on...
Prevalence and associated factors of sarcopenia in cervical cancer patients undergoing chemotherapy
Prevalence and associated factors of sarcopenia in cervical cancer patients undergoing chemotherapy
Abstract
Background: Sarcopenia is a poor prognostic factor that negatively impacts overall survival and quality of life in cancer patients. The objective of our study was ...

