Search engine for discovering works of Art, research articles, and books related to Art and Culture
ShareThis
Javascript must be enabled to continue!

Facility type and it's impact on survival in Ewing's sarcoma: An NCDB analysis.

View through CrossRef
e23505 Background: Previous studies have reported a significant association between facility type and survival in cancer patients. This study aimed to investigate the impact of treatment facility type on overall survival for Ewing’s Sarcoma. A secondary objective was to identify differences in distribution of demographic variables between facility types. Methods: The National Cancer Database (NCDB) was used to identify patients diagnosed with Ewing’s sarcoma from 2004 to 2018. Four facility types were identified: Academic/Research Programs, Community Cancer Programs, Comprehensive Community Center Programs, and Integrated Network Cancer Programs. Descriptive statistics and Kaplan Meier curves were used to measure survival in these patients and Chi-square was used to evaluate differences in demographics. Data was analyzed using SPSS and statistical significance was set at α = 0.05. Results: Of 269 patients queried, 49% were treated at an academic facility. Academic Programs had the longest median survival of 54 months; Community Cancer Programs had the shortest median survival of 9 months. Statistically significant survival differences were found between all facility types on log-rank comparison (p < 0.050), except for survival between Integrated Network and Community Cancer Programs (p = 0.162). Academic Programs had the highest overall survival when compared to Community Cancer Programs (p = 0.000), Comprehensive Community Cancer Programs (p = 0.026), and Integrated Cancer Networks p = (0.003). Chi-Square analysis revealed an association between facility type and cancer stage at diagnosis (p = 0.044) as well as between facility type and primary payer status (p = 0.026). Notably, 58% of patients treated at Community Programs presented with stage IV disease and 41% were insured by Medicare. Additional log-rank comparisons and Kaplan Meier curves showed private insurance was associated with significantly higher survival compared with Medicaid (p = 0.043), Medicare (p = 0.001) and uninsured patients (p = 0.010). Patients treated at Comprehensive Community (70%) and Academic Programs (67%) had the highest proportion of patients with private insurance. Conclusions: This study showed that Ewing Sarcoma patients treated in an Academic/Research program facility experienced increased survival compared with other facility types. Patients treated at Community Cancer Programs were more likely to present with stage IV disease and were more likely to be on Medicare. Future studies may investigate additional factors that influence potential barriers to care for Ewing Sarcoma patients.[Table: see text]
Title: Facility type and it's impact on survival in Ewing's sarcoma: An NCDB analysis.
Description:
e23505 Background: Previous studies have reported a significant association between facility type and survival in cancer patients.
This study aimed to investigate the impact of treatment facility type on overall survival for Ewing’s Sarcoma.
A secondary objective was to identify differences in distribution of demographic variables between facility types.
Methods: The National Cancer Database (NCDB) was used to identify patients diagnosed with Ewing’s sarcoma from 2004 to 2018.
Four facility types were identified: Academic/Research Programs, Community Cancer Programs, Comprehensive Community Center Programs, and Integrated Network Cancer Programs.
Descriptive statistics and Kaplan Meier curves were used to measure survival in these patients and Chi-square was used to evaluate differences in demographics.
Data was analyzed using SPSS and statistical significance was set at α = 0.
05.
Results: Of 269 patients queried, 49% were treated at an academic facility.
Academic Programs had the longest median survival of 54 months; Community Cancer Programs had the shortest median survival of 9 months.
Statistically significant survival differences were found between all facility types on log-rank comparison (p < 0.
050), except for survival between Integrated Network and Community Cancer Programs (p = 0.
162).
Academic Programs had the highest overall survival when compared to Community Cancer Programs (p = 0.
000), Comprehensive Community Cancer Programs (p = 0.
026), and Integrated Cancer Networks p = (0.
003).
Chi-Square analysis revealed an association between facility type and cancer stage at diagnosis (p = 0.
044) as well as between facility type and primary payer status (p = 0.
026).
Notably, 58% of patients treated at Community Programs presented with stage IV disease and 41% were insured by Medicare.
Additional log-rank comparisons and Kaplan Meier curves showed private insurance was associated with significantly higher survival compared with Medicaid (p = 0.
043), Medicare (p = 0.
001) and uninsured patients (p = 0.
010).
Patients treated at Comprehensive Community (70%) and Academic Programs (67%) had the highest proportion of patients with private insurance.
Conclusions: This study showed that Ewing Sarcoma patients treated in an Academic/Research program facility experienced increased survival compared with other facility types.
Patients treated at Community Cancer Programs were more likely to present with stage IV disease and were more likely to be on Medicare.
Future studies may investigate additional factors that influence potential barriers to care for Ewing Sarcoma patients.
[Table: see text].

Related Results

Pembrolizumab and Sarcoma: A meta-analysis
Pembrolizumab and Sarcoma: A meta-analysis
Abstract Introduction: Pembrolizumab is a monoclonal antibody that promotes antitumor immunity. This study presents a systematic review and meta-analysis of the efficacy and safety...
Renal Ewing Sarcoma: A Case Report and Literature Review
Renal Ewing Sarcoma: A Case Report and Literature Review
Abstract Introduction Primary renal Ewing sarcoma is an extremely rare and aggressive tumor, representing less than 1% of all renal tumors. This case report contributes valuable in...
Data from BRCA1-Associated RING Domain-1 (BARD1) Loss and GBP1 Expression Enhance Sensitivity to DNA Damage in Ewing Sarcoma
Data from BRCA1-Associated RING Domain-1 (BARD1) Loss and GBP1 Expression Enhance Sensitivity to DNA Damage in Ewing Sarcoma
<div><p>Ewing sarcoma is a fusion oncoprotein–driven primary bone tumor. A subset of patients (∼10%) with Ewing sarcoma are known to harbor germline variants in a growi...
The risk of developing acute myeloid leukaemia in patients with Ewing’s sarcoma and trend analysis: A SEER-based study
The risk of developing acute myeloid leukaemia in patients with Ewing’s sarcoma and trend analysis: A SEER-based study
Abstract Background Ewing sarcoma is a neoplasm of neuroectodermal origin arising from bone or soft tissue. The annual incidence of Ewing sarcoma is 2.93 children per 1,000...
Construction of a Prognostic Signature in Ewing’s Sarcoma: Based on RNA-binding Genes
Construction of a Prognostic Signature in Ewing’s Sarcoma: Based on RNA-binding Genes
Abstract Background: Ewing’s sarcoma is the second most prevalent primary malignant bone neoplasm. RNA-binding proteins(RBPs) play a crucial role in post-transcriptional ev...
Ewing's Sarcoma: A Case Report
Ewing's Sarcoma: A Case Report
Ewing’s sarcoma is a bone tumor, considered one of the most aggressive, for its great capacity of metastasizing. Higher incidence in men, appears almost exclusively in the first th...
Current Status of Proteomics in Ewing's Sarcoma
Current Status of Proteomics in Ewing's Sarcoma
AbstractEwing's sarcoma is an extremely rare mesenchymal malignancy of the bone, which predominantly occurs in children and young adolescents. Ewing's sarcoma is characterized by c...
Are Cervical Ribs Indicators of Childhood Cancer? A Narrative Review
Are Cervical Ribs Indicators of Childhood Cancer? A Narrative Review
Abstract A cervical rib (CR), also known as a supernumerary or extra rib, is an additional rib that forms above the first rib, resulting from the overgrowth of the transverse proce...

Back to Top