Restless Legs, Relentless Pressure: The Non-Dipping Pattern in Restless Legs Syndrome Beyond Shared Comorbidities

Abstract Background Non-dipping blood pressure pattern, characterized by a blunted nocturnal decline in blood pressure, is associated with increased cardiovascular morbidity and mortality. Restless legs syndrome (RLS) has been linked to sympathetic hyperactivity and altered circadian regulation, potentially contributing to abnormal blood pressure patterns. This study aimed to evaluate the relationship between RLS and non-dipping pattern in patients undergoing ambulatory blood pressure monitoring. Methods In this prospective observational study, 501 eligible participants were included after excluding those with obstructive sleep apnea syndrome, type 1 diabetes, or morbid obesity. RLS was diagnosed according to National Institutes of Health consensus criteria using clinical assessment, the International RLS Study Group scale, and the Berlin Questionnaire. A non-dipping pattern was defined as <10% nocturnal reduction in mean systolic or diastolic blood pressure. Results RLS was diagnosed in 158 patients (31.5%). Compared with controls, RLS patients were more often female and had higher rates of diabetes and hyperlipidemia. Non-dipping was significantly more prevalent in the RLS group (69.0% vs 48.7%, P < .001), accompanied by lower systolic and diastolic blood pressure variability (both P < .001). In multivariable logistic regression, independent predictors of RLS included female sex (β = 0.701, P = .049), hyperlipidemia (β = 0.850, P = .031), and non-dipping status (β = 1.057, P < .001). Receiver operating characteristic analysis demonstrated modest predictive ability (area under the curve = 0.601; 95% confidence interval 0.557–0.645). Conclusions RLS is independently associated with a non-dipping blood pressure pattern, even after excluding major confounders. These findings suggest a shared autonomic mechanism linking RLS with impaired nocturnal blood pressure regulation and heightened cardiovascular risk.