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Prostacyclin: A Potent Antimetastatic Agent
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Metastasis is the principal cause of failures to cure human cancers. Prostacyclin is a powerful antimetastatic agent against B16 amelanotic melanoma cells. This effect, which may result from the platelet antiaggregatory action of prostacyclin, is potentiated by a phosphodiesterase inhibitor. Inhibitors of prostacyclin synthesis increase metastasis. Prostacyclin and agents that may increase endogenous prostacyclin production or prolong its activity are suggested as new antimetastatic agents.
American Association for the Advancement of Science (AAAS)
Title: Prostacyclin: A Potent Antimetastatic Agent
Description:
Metastasis is the principal cause of failures to cure human cancers.
Prostacyclin is a powerful antimetastatic agent against B16 amelanotic melanoma cells.
This effect, which may result from the platelet antiaggregatory action of prostacyclin, is potentiated by a phosphodiesterase inhibitor.
Inhibitors of prostacyclin synthesis increase metastasis.
Prostacyclin and agents that may increase endogenous prostacyclin production or prolong its activity are suggested as new antimetastatic agents.
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