Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
EEF1A1 deacetylation enables transcriptional activation of remyelination
View through CrossRef
AbstractRemyelination of the peripheral and central nervous systems (PNS and CNS, respectively) is a prerequisite for functional recovery after lesion. However, this process is not always optimal and becomes inefficient in the course of multiple sclerosis. Here we show that, when acetylated, eukaryotic elongation factor 1A1 (eEF1A1) negatively regulates PNS and CNS remyelination. Acetylated eEF1A1 (Ac-eEF1A1) translocates into the nucleus of myelinating cells where it binds to Sox10, a key transcription factor for PNS and CNS myelination and remyelination, to drag Sox10 out of the nucleus. We show that the lysine acetyltransferase Tip60 acetylates eEF1A1, whereas the histone deacetylase HDAC2 deacetylates eEF1A1. Promoting eEF1A1 deacetylation maintains the activation of Sox10 target genes and increases PNS and CNS remyelination efficiency. Taken together, these data identify a major mechanism of Sox10 regulation, which appears promising for future translational studies on PNS and CNS remyelination.
Springer Science and Business Media LLC
Title: EEF1A1 deacetylation enables transcriptional activation of remyelination
Description:
AbstractRemyelination of the peripheral and central nervous systems (PNS and CNS, respectively) is a prerequisite for functional recovery after lesion.
However, this process is not always optimal and becomes inefficient in the course of multiple sclerosis.
Here we show that, when acetylated, eukaryotic elongation factor 1A1 (eEF1A1) negatively regulates PNS and CNS remyelination.
Acetylated eEF1A1 (Ac-eEF1A1) translocates into the nucleus of myelinating cells where it binds to Sox10, a key transcription factor for PNS and CNS myelination and remyelination, to drag Sox10 out of the nucleus.
We show that the lysine acetyltransferase Tip60 acetylates eEF1A1, whereas the histone deacetylase HDAC2 deacetylates eEF1A1.
Promoting eEF1A1 deacetylation maintains the activation of Sox10 target genes and increases PNS and CNS remyelination efficiency.
Taken together, these data identify a major mechanism of Sox10 regulation, which appears promising for future translational studies on PNS and CNS remyelination.
Related Results
THE EFFECT OF TIME DEACETYLATION TO CHARACTERIZE CHITOSAN FROM WASTE SHRIMP
THE EFFECT OF TIME DEACETYLATION TO CHARACTERIZE CHITOSAN FROM WASTE SHRIMP
This research aims to look at the effect of time deacetylation of the chitosan characterization of the results of the utilization of waste shrimp. The method was used in this resea...
PENGARUH WAKTU PROSES DEASETILASI KITIN DARI CANGKANG BEKICOT (Achatina fulica) TERHADAP DERAJAT DEASETILASI
PENGARUH WAKTU PROSES DEASETILASI KITIN DARI CANGKANG BEKICOT (Achatina fulica) TERHADAP DERAJAT DEASETILASI
ABSTRACT Research on the effect of chitin deacetylation processing times from shells of snails on the degree of deacetylation has conducted with a variations of 60 minutes, 90 minu...
Investigating the Effect of Deacetylation Temperature on the Characterization of Chitosan from Crab Shells as a Candidate for Organic Nanofluids
Investigating the Effect of Deacetylation Temperature on the Characterization of Chitosan from Crab Shells as a Candidate for Organic Nanofluids
Chitosan has been broadly utilized in bone scaffold production because of its antibacterial qualities, low toxicity, biodegradability, biocompatibility, and ability to aid regenera...
Evaluating the Role of the Kappa Opioid Receptor Nalfurafine in Preclinical Models of Demyelination
Evaluating the Role of the Kappa Opioid Receptor Nalfurafine in Preclinical Models of Demyelination
Multiple sclerosis (MS) is a neurodegenerative autoimmune disease affecting the central nervous system (CNS), impacting more than 2.9 million people worldwide with increasing preva...
Transcriptional Regulation Underlying Long-term Sensitization in Aplysia
Transcriptional Regulation Underlying Long-term Sensitization in Aplysia
The final published article is available in the Oxford Research Encyclopedia of Neuroscience: https://oxfordre.com/neuroscience/display/10.1093/acrefore/9780190264086.001.0001/acre...
Abstract 1786: UV damage-induced histone H3 lysine 56 deacetylation regulates nucleotide excision repair and checkpoint signaling.
Abstract 1786: UV damage-induced histone H3 lysine 56 deacetylation regulates nucleotide excision repair and checkpoint signaling.
Abstract
Nucleotide excision repair (NER) is the major pathway in cells for the removal of bulky photoproducts and ensuring integrity of the genome. NER constitutes ...
Transcriptomic Analysis Reveals the Key Role of Histone Deacetylation-mediated Phytohormones Interaction in Fiber Initiation of Cotton
Transcriptomic Analysis Reveals the Key Role of Histone Deacetylation-mediated Phytohormones Interaction in Fiber Initiation of Cotton
Abstract
Background: Histone deacetylation is one of the most important epigenetic modifications and plays diverse roles in plant development. However, the detailed functio...
Neuregulin‐1 promotes remyelination and fosters a pro‐regenerative inflammatory response in focal demyelinating lesions of the spinal cord
Neuregulin‐1 promotes remyelination and fosters a pro‐regenerative inflammatory response in focal demyelinating lesions of the spinal cord
AbstractOligodendroglial cell death and demyelination are hallmarks of neurotrauma and multiple sclerosis that cause axonal damage and functional impairments. Remyelination remains...