Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
EEF1A1 deacetylation enables transcriptional activation of remyelination
View through CrossRef
AbstractRemyelination of the peripheral and central nervous systems (PNS and CNS, respectively) is a prerequisite for functional recovery after lesion. However, this process is not always optimal and becomes inefficient in the course of multiple sclerosis. Here we show that, when acetylated, eukaryotic elongation factor 1A1 (eEF1A1) negatively regulates PNS and CNS remyelination. Acetylated eEF1A1 (Ac-eEF1A1) translocates into the nucleus of myelinating cells where it binds to Sox10, a key transcription factor for PNS and CNS myelination and remyelination, to drag Sox10 out of the nucleus. We show that the lysine acetyltransferase Tip60 acetylates eEF1A1, whereas the histone deacetylase HDAC2 deacetylates eEF1A1. Promoting eEF1A1 deacetylation maintains the activation of Sox10 target genes and increases PNS and CNS remyelination efficiency. Taken together, these data identify a major mechanism of Sox10 regulation, which appears promising for future translational studies on PNS and CNS remyelination.
Springer Science and Business Media LLC
Title: EEF1A1 deacetylation enables transcriptional activation of remyelination
Description:
AbstractRemyelination of the peripheral and central nervous systems (PNS and CNS, respectively) is a prerequisite for functional recovery after lesion.
However, this process is not always optimal and becomes inefficient in the course of multiple sclerosis.
Here we show that, when acetylated, eukaryotic elongation factor 1A1 (eEF1A1) negatively regulates PNS and CNS remyelination.
Acetylated eEF1A1 (Ac-eEF1A1) translocates into the nucleus of myelinating cells where it binds to Sox10, a key transcription factor for PNS and CNS myelination and remyelination, to drag Sox10 out of the nucleus.
We show that the lysine acetyltransferase Tip60 acetylates eEF1A1, whereas the histone deacetylase HDAC2 deacetylates eEF1A1.
Promoting eEF1A1 deacetylation maintains the activation of Sox10 target genes and increases PNS and CNS remyelination efficiency.
Taken together, these data identify a major mechanism of Sox10 regulation, which appears promising for future translational studies on PNS and CNS remyelination.
Related Results
Investigating the Effect of Deacetylation Temperature on the Characterization of Chitosan from Crab Shells as a Candidate for Organic Nanofluids
Investigating the Effect of Deacetylation Temperature on the Characterization of Chitosan from Crab Shells as a Candidate for Organic Nanofluids
Chitosan has been broadly utilized in bone scaffold production because of its antibacterial qualities, low toxicity, biodegradability, biocompatibility, and ability to aid regenera...
Transcriptional Regulation Underlying Long-term Sensitization in Aplysia
Transcriptional Regulation Underlying Long-term Sensitization in Aplysia
The final published article is available in the Oxford Research Encyclopedia of Neuroscience: https://oxfordre.com/neuroscience/display/10.1093/acrefore/9780190264086.001.0001/acre...
Abstract 1786: UV damage-induced histone H3 lysine 56 deacetylation regulates nucleotide excision repair and checkpoint signaling.
Abstract 1786: UV damage-induced histone H3 lysine 56 deacetylation regulates nucleotide excision repair and checkpoint signaling.
Abstract
Nucleotide excision repair (NER) is the major pathway in cells for the removal of bulky photoproducts and ensuring integrity of the genome. NER constitutes ...
Mediator kinase submodule-dependent regulation of cardiac transcription
Mediator kinase submodule-dependent regulation of cardiac transcription
<p>Pathological cardiac remodeling results from myocardial stresses including pressure and volume overload, neurohumoral activation, myocardial infarction, and hypothyroidism...
Glial grafting for demyelinating disease
Glial grafting for demyelinating disease
Remyelination of demyelinated central nervous system (CNS) axons is considered as a potential treatment for multiple sclerosis, and it has been achieved in experimental models of d...
Kinetics of N-Deacetylation of Chitin Extracted from Shrimp Shells Collected from Coastal Area of Morocco
Kinetics of N-Deacetylation of Chitin Extracted from Shrimp Shells Collected from Coastal Area of Morocco
Chitosan was obtained from the alkaline N-deacetylation of ï¡-chitin, derived from shrimp shells (SS) collected from the Moroccan coast. Effects of temperature, NaOH concentration...
Validation of novel reference genes for RT‐qPCR studies of gene expression in Xenopus tropicalis during embryonic and post‐embryonic development
Validation of novel reference genes for RT‐qPCR studies of gene expression in Xenopus tropicalis during embryonic and post‐embryonic development
Background: Accurate interpretation of transcriptome profiling by quantitative PCR requires the establishment of species‐specific standards. However, the selection of reference gen...
KARAKTERISASI KITOSAN CANGKANG LANDAK LAUT JENIS Tripneustes Gratilla DENGAN DEASETILASI KONSENTRASI NaOH YANG BERBEDA
KARAKTERISASI KITOSAN CANGKANG LANDAK LAUT JENIS Tripneustes Gratilla DENGAN DEASETILASI KONSENTRASI NaOH YANG BERBEDA
The population of sea urchin Tripneustes gratilla in Tidore City, North Maluku Province, is very abundant and rich in chitosan sources. This variety of sea urchin can be used as a ...