Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Increased Incidence of Villitis in Placentas Exposed to Chemotherapy During Pregnancy: Is There a Correlation?
View through CrossRef
We have identified 9 pregnant patients who were diagnosed with malignancy and initiated chemotherapy during their second trimester (cervical cancer [n = 3], leukemia [n = 3], breast cancer [n = 2], and Hodgkin’s lymphoma [n = 1]). Five of the patients’ placentas were small for gestational age (SGA). Pathologic examination revealed inflammatory changes in 4 of the placentas: 2 from the SGA placentas and 2 from non-SGA placentas. Examination revealed 3 placentas with villitis of unknown etiology (VUE) and 1 with intervillositis; all were negative for bacterial and viral cultures and by immunohistochemical (IHC) stains. In the VUE cases, IHC stains showed positivity of CD25+/FOXP3+ with focal positivity and CD3 and CD4 IHC were focally to strongly positive. Literature suggests that the use of chemotherapy during pregnancy can be detrimental to both the mother and the fetus; however, there has been limited focus on the effects of chemotherapy on the placenta. We suggest that the inflammatory process noted in the placentas is due to chemotherapy-induced toxic effects.
Title: Increased Incidence of Villitis in Placentas Exposed to Chemotherapy During Pregnancy: Is There a Correlation?
Description:
We have identified 9 pregnant patients who were diagnosed with malignancy and initiated chemotherapy during their second trimester (cervical cancer [n = 3], leukemia [n = 3], breast cancer [n = 2], and Hodgkin’s lymphoma [n = 1]).
Five of the patients’ placentas were small for gestational age (SGA).
Pathologic examination revealed inflammatory changes in 4 of the placentas: 2 from the SGA placentas and 2 from non-SGA placentas.
Examination revealed 3 placentas with villitis of unknown etiology (VUE) and 1 with intervillositis; all were negative for bacterial and viral cultures and by immunohistochemical (IHC) stains.
In the VUE cases, IHC stains showed positivity of CD25+/FOXP3+ with focal positivity and CD3 and CD4 IHC were focally to strongly positive.
Literature suggests that the use of chemotherapy during pregnancy can be detrimental to both the mother and the fetus; however, there has been limited focus on the effects of chemotherapy on the placenta.
We suggest that the inflammatory process noted in the placentas is due to chemotherapy-induced toxic effects.
Related Results
Playing Pregnancy: The Ludification and Gamification of Expectant Motherhood in Smartphone Apps
Playing Pregnancy: The Ludification and Gamification of Expectant Motherhood in Smartphone Apps
IntroductionLike other forms of embodiment, pregnancy has increasingly become subject to representation and interpretation via digital technologies. Pregnancy and the unborn entity...
Microwave Ablation with or Without Chemotherapy in Management of Non-Small Cell Lung Cancer: A Systematic Review
Microwave Ablation with or Without Chemotherapy in Management of Non-Small Cell Lung Cancer: A Systematic Review
Abstract
Introduction
Microwave ablation (MWA) has emerged as a minimally invasive treatment for patients with inoperable non-small cell lung cancer (NSCLC). However, whether it i...
Nutrition in pregnancy
Nutrition in pregnancy
SUMMARY
INTRODUCTION
PHYSIOLOGICAL CHANGES DURING PREGNANCY
Changes in body composition and weight gain
Changes in blood composition
Metabolic changes and adaptive responses
K...
Tumorigenic Factor CRIPTO-1 Is Immunolocalized in Extravillous Cytotrophoblast in Placenta Creta
Tumorigenic Factor CRIPTO-1 Is Immunolocalized in Extravillous Cytotrophoblast in Placenta Creta
CRIPTO-(CR)1 is a protein associated with tumorigenesis and metastasis. Here we demonstrate that CR-1 expression in normal and creta placentas is associated with various degrees of...
Renal Ewing Sarcoma: A Case Report and Literature Review
Renal Ewing Sarcoma: A Case Report and Literature Review
Abstract
Introduction
Primary renal Ewing sarcoma is an extremely rare and aggressive tumor, representing less than 1% of all renal tumors. This case report contributes valuable in...
CHANGES IN THE INTENSITY OF UTERINE CIRCULATION IN PREGNANT WOMEN WITH A HISTORY OF CHRONIC ENDOMETRITIS
CHANGES IN THE INTENSITY OF UTERINE CIRCULATION IN PREGNANT WOMEN WITH A HISTORY OF CHRONIC ENDOMETRITIS
Introduction. An essential prerequisite for the normal course of pregnancy is a complete gestational remodeling of the blood circulation, when the spiral arteries are transformed i...
Changes in oral microbiota after the initiation of chemotherapy in patients with hematopoietic tumors
Changes in oral microbiota after the initiation of chemotherapy in patients with hematopoietic tumors
Abstract
Background
Recently, the gut microbiota has been shown to play an important role in the response and resistance to chemotherapy. Although there is much knowledge ...
Compare the Histological Features between the Normal and Hypertensive Placenta
Compare the Histological Features between the Normal and Hypertensive Placenta
Objective: The purpose of the current research was to investigate the morphology and histology of placentas collected from moms who had PIH and to compare those results to placenta...