Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
RECQ5: A Mysterious Helicase at the Interface of DNA Replication and Transcription
View through CrossRef
RECQ5 belongs to the RecQ family of DNA helicases. It is conserved from Drosophila to humans and its deficiency results in genomic instability and cancer susceptibility in mice. Human RECQ5 is known for its ability to regulate homologous recombination by disrupting RAD51 nucleoprotein filaments. It also binds to RNA polymerase II (RNAPII) and negatively regulates transcript elongation by RNAPII. Here, we summarize recent studies implicating RECQ5 in the prevention and resolution of transcription-replication conflicts, a major intrinsic source of genomic instability during cancer development.
Title: RECQ5: A Mysterious Helicase at the Interface of DNA Replication and Transcription
Description:
RECQ5 belongs to the RecQ family of DNA helicases.
It is conserved from Drosophila to humans and its deficiency results in genomic instability and cancer susceptibility in mice.
Human RECQ5 is known for its ability to regulate homologous recombination by disrupting RAD51 nucleoprotein filaments.
It also binds to RNA polymerase II (RNAPII) and negatively regulates transcript elongation by RNAPII.
Here, we summarize recent studies implicating RECQ5 in the prevention and resolution of transcription-replication conflicts, a major intrinsic source of genomic instability during cancer development.
Related Results
DNA replication initiation and fidelity : a nanoscale view of the code of life
DNA replication initiation and fidelity : a nanoscale view of the code of life
<p dir="ltr">Every time a cell divides it needs to copy its entire genome. This is a fragile and challenging task, involving billions of DNA base pairs, tightly bound protein...
DNA replication initiation and fidelity : a nanoscale view of the code of life
DNA replication initiation and fidelity : a nanoscale view of the code of life
<p dir="ltr">Every time a cell divides it needs to copy its entire genome. This is a fragile and challenging task, involving billions of DNA base pairs, tightly bound protein...
DNA replication initiation and fidelity: a nanoscale view of the code of life
DNA replication initiation and fidelity: a nanoscale view of the code of life
<p dir="ltr">Every time a cell divides it needs to copy its entire genome. This is a fragile and challenging task, involving billions of DNA base pairs, tightly bound protein...
Mechanisms of transcription attenuation and condensation of RNA polymerase II by RECQ5
Mechanisms of transcription attenuation and condensation of RNA polymerase II by RECQ5
Abstract
The elongation rates of RNA polymerase II (RNAPII) require precise control to prevent transcriptional stress, which can impede co-transc...
Implication de la co-hélicase DciA dans la réplication chez Vibrio cholerae
Implication de la co-hélicase DciA dans la réplication chez Vibrio cholerae
Lors de la réplication bactérienne, les hélicases réplicatives séparent les deux brins d'ADN devant la fourche de réplication. Chez les bactéries, la gestion de ces hélicases penda...
A risky journey for Break-Induced Replication
A risky journey for Break-Induced Replication
Break Induced Replication (BIR) is one of the homologous recombination pathways to repair DNA double strand breaks. BIR plays important roles in main- taining genomic integrity. Fo...
Mapping of helicase and helicase substrate-binding domains on simian virus 40 large T antigen
Mapping of helicase and helicase substrate-binding domains on simian virus 40 large T antigen
We generated fragments of simian virus 40 large tumor antigen (T antigen) by tryptic digestion and assayed them for helicase activity and helicase substrate (mostly single-stranded...
Genome wide hypomethylation and youth-associated DNA gap reduction promoting DNA damage and senescence-associated pathogenesis
Genome wide hypomethylation and youth-associated DNA gap reduction promoting DNA damage and senescence-associated pathogenesis
Abstract
Background: Age-associated epigenetic alteration is the underlying cause of DNA damage in aging cells. Two types of youth-associated DNA-protection epigenetic mark...