Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
RECQ5: A Mysterious Helicase at the Interface of DNA Replication and Transcription
View through CrossRef
RECQ5 belongs to the RecQ family of DNA helicases. It is conserved from Drosophila to humans and its deficiency results in genomic instability and cancer susceptibility in mice. Human RECQ5 is known for its ability to regulate homologous recombination by disrupting RAD51 nucleoprotein filaments. It also binds to RNA polymerase II (RNAPII) and negatively regulates transcript elongation by RNAPII. Here, we summarize recent studies implicating RECQ5 in the prevention and resolution of transcription-replication conflicts, a major intrinsic source of genomic instability during cancer development.
Title: RECQ5: A Mysterious Helicase at the Interface of DNA Replication and Transcription
Description:
RECQ5 belongs to the RecQ family of DNA helicases.
It is conserved from Drosophila to humans and its deficiency results in genomic instability and cancer susceptibility in mice.
Human RECQ5 is known for its ability to regulate homologous recombination by disrupting RAD51 nucleoprotein filaments.
It also binds to RNA polymerase II (RNAPII) and negatively regulates transcript elongation by RNAPII.
Here, we summarize recent studies implicating RECQ5 in the prevention and resolution of transcription-replication conflicts, a major intrinsic source of genomic instability during cancer development.
Related Results
Mechanisms of transcription attenuation and condensation of RNA polymerase II by RECQ5
Mechanisms of transcription attenuation and condensation of RNA polymerase II by RECQ5
Abstract
The elongation rates of RNA polymerase II (RNAPII) require precise control to prevent transcriptional stress, which can impede co-transc...
A risky journey for Break-Induced Replication
A risky journey for Break-Induced Replication
Break Induced Replication (BIR) is one of the homologous recombination pathways to repair DNA double strand breaks. BIR plays important roles in main- taining genomic integrity. Fo...
Mapping of helicase and helicase substrate-binding domains on simian virus 40 large T antigen
Mapping of helicase and helicase substrate-binding domains on simian virus 40 large T antigen
We generated fragments of simian virus 40 large tumor antigen (T antigen) by tryptic digestion and assayed them for helicase activity and helicase substrate (mostly single-stranded...
Genome wide hypomethylation and youth-associated DNA gap reduction promoting DNA damage and senescence-associated pathogenesis
Genome wide hypomethylation and youth-associated DNA gap reduction promoting DNA damage and senescence-associated pathogenesis
Abstract
Background: Age-associated epigenetic alteration is the underlying cause of DNA damage in aging cells. Two types of youth-associated DNA-protection epigenetic mark...
Genome wide hypomethylation and youth-associated DNA gap reduction promoting DNA damage and senescence-associated pathogenesis
Genome wide hypomethylation and youth-associated DNA gap reduction promoting DNA damage and senescence-associated pathogenesis
Introduction: The United States currently faces two opioid crises, an evolved crisis currently manifesting as widespread abuse of illicit opioids, and a crisis in pain management l...
Senataxin RNA/DNA helicase promotes replication restart at co-transcriptional R-loops to prevent MUS81-dependent fork degradation
Senataxin RNA/DNA helicase promotes replication restart at co-transcriptional R-loops to prevent MUS81-dependent fork degradation
Abstract
Replication forks stalled at co-transcriptional R-loops can be restarted by a mechanism involving fork cleavage-religation cycles mediated by MUS81 endonucl...
Essential and non-essential DNA replication genes in the model halophilic Archaeon, Halobacterium sp. NRC-1
Essential and non-essential DNA replication genes in the model halophilic Archaeon, Halobacterium sp. NRC-1
Abstract
Background
Information transfer systems in Archaea, including many components of the DNA replication machinery, are similar to those fou...
Chromatin-dependent pre-replication complex positioning and activation in mammals
Chromatin-dependent pre-replication complex positioning and activation in mammals
Positionnement et activation du complexe de pré-réplication dépendant de la chromatine dans les mammifères
Chaque division cellulaire requiert une duplication préci...