Atalantia Racemosa Wight Mitigates Arthritis Through the Modulation of Crucial Immune Mediators of Inflammation in an Experimental Arthritis Model

Objective The persistent need to discover plant species with anti-arthritic properties prompted the investigation of A. racemosa Wight. The objective is to study anti-arthritic attributes of ethanolic extracts made from A. racemosa leaves and stems. Methods Using in vivo model, the anti-arthritic property was evaluated. Acute toxicity was performed as per OECD strategies to determine dose. Formaldehydeinduced model was used to investigate anti-arthritic action. 200 mg/kg of ethanolic extracts of leaves and stems were given orally. To know the antiarthritic potential of A. racemosa radiology as well as histopathology was performed. Results The stem ethanolic extract demonstrated significant reduction in arthritis by showing 49.65% inhibition than leaf ethanolic extract which shows 38.89% inhibition. Chemical examination of the plant's ethanolic leaf and stem extracts shown existence of flavonoids, terpenoids, and steroids. Antiarthritic activity of A. racemosa is supported by histopathology, radiology and haematological analysis. Conclusion This study indicates that A. racemosa may be useful as a bioactive chemical source for the treatment of inflammatory disorders and orthopedic pain.