Cucurbit[n]urils Based Molecular Recognition with Fluorescence Signalling

<div>The development of fluorescence based supramolecules offering selectivity,</div><div>sensitivity and detection in real time applications are of great interest. Cucurbit[n]urils</div><div>(CB[n]), a macrocyclic synthetic host molecule consists of a varying number of</div><div>glycoluril units bridged by methylene groups. CB[n]s easily forms host-guest</div><div>complexes (inclusion complexes) with a wide range of analytes. The recognition of</div><div>analytes in the presence of host molecules using fluorescence techniques received</div><div>greater attention due to its rapid response, high sensitivity to the environment and</div><div>robust adaptability. Exploiting the fluorescence properties of CB[n] based</div><div>supramolecules by enhancing or quenching the fluorescence intensity in the presence of</div><div>guest molecules by spectrofluorometric methods is discussed. A brief outlook on the</div><div>development of fluorescence properties of CB[n] based supramolecules used for</div><div>imaging and photodynamic therapy is presented and discussed.</div>