Abstract 213: Interleukins 17 a and 22: Are There Differences in Blood Concentrations of Patients With or Without Atherosclerosis ?

Introduction: The role of the immune and inflammatory pathways in patients with atherosclerosis is important but not complete understood. The objective of this study was to evaluate if patients with coronary atherosclerosis have higher concentrations of interleukins 17 A and 22 when compared to patients without carotid atherosclerosis. Hypothesis: There are higher concentrations of interleukins 17 A and 22 in patients with coronary artery disease than in patients without carotid disease Methods: This is a cross-sectional, prospective, analytical study, conducted from August to December 2015, that enrolled 60 patients. We included 30 patients with stable CAD with coronary stenosis ≥ 50% according to current coronary angiography and 30 patients with chronic infectious parasitic disease without carotid atherosclerosis according to intimal medial thickness. Interleukins (IL) were evaluated in serum of patients. IL concentrations were expressed in pg / ml and the detectable minimum values of interleukins were: 17A = 15.62 pg/ml and 22 = 7.81 pg/ml. Descriptive and analytical statistical analyzes were performed. The Shapiro-Wilk normality test was applied to verify the normality of the data. Statistical tests were used to compare the variables and p-value < 0.05 was significant Results: There were 18 men and 12 women in the group of patients with coronary disease and 14 men and 16 patients without carotid disease. The main CAD risk factors (in the group of patients with coronary atherosclerosis) were: Hypertension 63%, Diabetes Mellitus 40%, dyslipidemia 33%, smoking 23%. The serum concentrations of interleukins 17A showed: patients with coronary atherosclerosis = 15.62 pg/ml vs patients without carotid atherosclerosis = 15.62 pg/ml. Serum concentrations of interleukins 22 showed: patients with coronary atherosclerosis = 7.81 pg/ml vs patients without carotid atherosclerosis = 7.81 pg/ml. Conclusions: Interleukin 17 and 22 concentrations were low in both groups of patients and there were no differences between patients with coronary atherosclerosis and no carotid atherosclerosis. Therefore, it is possible that these interleukins measured may not identify who has coronary atherosclerosis and who does not have carotid atherosclerosis.