Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Facile Multicomponent Mannich Reaction towards Biologically Active Compounds
View through CrossRef
Abstract
The Mannich reaction is one of the most broadly used organic reactions for constructing C−N and C−C bonds in synthetic chemistry. This review focuses on the multicomponent Mannich reaction and its variants for the synthesis of biologically active moieties such as anticancer, antimicrobial, antimalarial, antitubercular, anti‐inflammatory and anticonvulsant molecules. A few organocatalyzed asymmetric Mannich reactions are also incorporated.
Title: Facile Multicomponent Mannich Reaction towards Biologically Active Compounds
Description:
Abstract
The Mannich reaction is one of the most broadly used organic reactions for constructing C−N and C−C bonds in synthetic chemistry.
This review focuses on the multicomponent Mannich reaction and its variants for the synthesis of biologically active moieties such as anticancer, antimicrobial, antimalarial, antitubercular, anti‐inflammatory and anticonvulsant molecules.
A few organocatalyzed asymmetric Mannich reactions are also incorporated.
Related Results
Isolation, characterization and semi-synthesis of natural products dimeric amide alkaloids
Isolation, characterization and semi-synthesis of natural products dimeric amide alkaloids
Isolation, characterization of natural products dimeric amide alkaloids from roots of the Piper chaba Hunter. The synthesis of these products using intermolecular [4+2] cycloaddit...
Synthetic applications of biologically important Mannich bases: An updated review
Synthetic applications of biologically important Mannich bases: An updated review
Mannich bases are the beta-amino ketones carrying compounds. Mannich reaction is a nucleophilic addition reaction (nucleophiles such as halogen ions (I-, Br-, Cl- ), the hydroxide ...
Synthesis and Antimicrobial Activities of Some Polyphenol Compounds by Nano ZnO-TBAB as a Heterogeneous Catalytic Media
Synthesis and Antimicrobial Activities of Some Polyphenol Compounds by Nano ZnO-TBAB as a Heterogeneous Catalytic Media
Introduction: Mannich reaction is a typical example of a three-component condensation reaction
and the chemistry of Mannich bases has been the matter of search by researchers. Here...
IMPROVED SOLUBILITY NOVEL MULTICOMPONENT CRYSTALS OF FENOFIBRIC ACID-ACETYLSALISYLIC ACID
IMPROVED SOLUBILITY NOVEL MULTICOMPONENT CRYSTALS OF FENOFIBRIC ACID-ACETYLSALISYLIC ACID
Solubility is an important physicochemical property of active pharmaceutical ingredients. Poor water solubility of active pharmaceutical ingredients leads to low bioavailability; t...
Mannich Reaction
Mannich Reaction
AbstractThis reaction is a multicomponent condensation between an amine, an enolizable carbonyl compound (donor), and a nonenolizable carbonyl compound (acceptor) to form a β‐amino...
Synthèse et réactions multicomposants d’espèces gem-bimétalliques
Synthèse et réactions multicomposants d’espèces gem-bimétalliques
Face au besoin de nouvelles méthodologies conjugué à une prise de conscience environnementale, les réactions multi-composants constituent une solution importante dans le développem...
Composition of biologically active substances of common cranberry fruits (Oxycoccus palustris Pers.) in various methods of preservation
Composition of biologically active substances of common cranberry fruits (Oxycoccus palustris Pers.) in various methods of preservation
Introduction. The study of common cranberry fruits is promising due to the wide variety of biologically active substances included in their composition, a wide range of therapeutic...
Perbaikan Kelarutan Albendazol Melalui Pembentukan Kristal Multikomponen dengan Asam Malat
Perbaikan Kelarutan Albendazol Melalui Pembentukan Kristal Multikomponen dengan Asam Malat
An effort to improve the solubility of albendazole (ABZ), an anthelmintic drug has been successfully carried out through the formation of multicomponent crystal with dl-malic acid ...