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Granular cell ameloblastoma: A diagnostic dilemma for histopathologist
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AbstractA rare case of granular cell ameloblastoma in the posterior mandible of a 45-year-old female has been studied both histologically and immunohistochemically. Histopathologically, hematoxylin and eosin and Periodic acid Schiff (PAS) prepared sections of granular cell ameloblastoma showed granular neoplastic cells residing within the tumor follicles. To characterize the granular cells in ameloblastoma, we examined the expression of low molecular weight cytokeratin and S-100 protein using immunohistochemistry. Granular cells exhibited positivity only with cytokeratin while S-100 protein was negative. This result allowed easy distinction of granular cell ameloblastomas from similar tumors exhibiting granular cell changes, and indicated that the granularity in ameloblastoma cells is consequent to lysosomal overload.
Georg Thieme Verlag KG
Title: Granular cell ameloblastoma: A diagnostic dilemma for histopathologist
Description:
AbstractA rare case of granular cell ameloblastoma in the posterior mandible of a 45-year-old female has been studied both histologically and immunohistochemically.
Histopathologically, hematoxylin and eosin and Periodic acid Schiff (PAS) prepared sections of granular cell ameloblastoma showed granular neoplastic cells residing within the tumor follicles.
To characterize the granular cells in ameloblastoma, we examined the expression of low molecular weight cytokeratin and S-100 protein using immunohistochemistry.
Granular cells exhibited positivity only with cytokeratin while S-100 protein was negative.
This result allowed easy distinction of granular cell ameloblastomas from similar tumors exhibiting granular cell changes, and indicated that the granularity in ameloblastoma cells is consequent to lysosomal overload.
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