Ceftriaxone Induced Anaphylaxis Reaction Following Negative Intradermal Skin Tested Patient: A Rare Case Report

Anaphylaxis is a severe life-threatening reaction that may be associated with exposure to a variety of drug classes. β-lactam antibiotics and nonsteroidal anti-inflammatory drugs (NSAIDs) are most common classes of drugs causing anaphylaxis. Intradermal skin test (IST) is required in absence of previous history of allergy to antibiotics. In spite of negative intradermal skin testing, our patient had severe anaphylactic reaction after ceftriaxone administration but was managed successfully. This case report reflects the limitations of screening test done preoperatively for the diagnosis of sensitization to ceftriaxone antibiotic drug. Key Messages: Intradermal skin test is mandatory in all patients receiving first exposure of any new antibiotic drug. When a patient is negative after intradermal skin test, the drug should be given as slow intravenous infusion to prevent sudden and dreadful cardiovascular collapse.