Endoscopic closure of tympanic membrane perforations by platelet-richplasma laden cartilage with perichondrium

Background: Myringoplasty surgery, also known as tympanic membrane repair, is performed to correct hearing loss brought on by TM perforation and to eliminate recurrent ear discharge. Platelets are the primary players in the process of tissue healing. They provide essential growth factors that stimulate fibroblasts to produce new blood vessels and lay down extracellular matrix. The study aim: Is to assess the efficacy of incorporating plateletrichplasma into tragal cartilage grafts with its perichondrium in order to speed healing and enhance the results of endoscopic transcanalmyringoplasty. Patients, and methods: Fifty people suffer from dry central TM perforation participated in this prospective case-control study. Under local anaesthesia, each of them had endoscopic transcanal myringoplasty by using tragal perichondrium grafts. 25 patients underwent myringoplasty surgery and also received platelet-richplasma (PRP) from the same patient in group A, compared to 25 patients in group B who underwent myringoplasty surgery but did not get PRP. Results: There were 25 patients in each group, and no statistically significant demographic differences existed between the two groups. A p-value of (0.01) indicates that there was a significant difference between the plattelet-rich plasma group's (100%) and the non-plattelet-rich plasma group's (72%) graft absorption success rates.