Comparison of two protocols for the management of post-partum hemorrhage. Retrospective study in two Belgian centers.

Abstract Post-partum hemorrhage complicates 3 to 5% of deliveries and is the leading cause of morbidity and mortality in the world. Management is often inadequate despite the existence of protocols. Objective: To compare the results of the management of women with post-partum hemorrhage due to uterine atony in two Belgian centers, one using Sulprostone and the other Misoprostol and Carboprost, in terms of use of 4th level techniques and total blood loss. Method: This is a retrospective study including patients with post-partum hemorrhage due to uterine atony after vaginal delivery requiring second-line uterotonic administration. The study period was from 1 January 2017 to 31 December 2022. Characteristics of the two populations, total losses, hemoglobin delta and management steps were collected. Results: In both institutions, patients had similar characteristics. The use of oxytocin, revision of the genital tract, administration of tranexamic acid, and use of fourth-line techniques were similar in both centers. Total losses and hemoglobin delta did not show any significant difference between the two protocols. Conclusion: The results of the two centers for post-partum hemorrhage due to uterine atony are similar despite the use of two different prostaglandins.