Clinical Features of Systemic Lupus Erythematosus-related Interstitial Lung Disease-a Clinical Retrospective Study

Abstract Background: There is no conclusion about the correlation between autoantibodies in SLE patients and ILD. In order to help early diagnosis of SLE-ILD, here we will compare the differences in clinical data of SLE-ILD and SLE-NILD patients and explore the clinical features of SLE-ILD and the value of indicators related to the diagnosis of SLE-ILD and independent risk factors. Methods: A clinical retrospective study. Select 89 SLE-ILD patients and 187 SLE-NILD patients, collect all patients' age of onset, smoking history, sex, and autoantibodies, and compare the differences between the two. Additionally collect respiratory manifestations, pulmonary auscultation signs, pulmonary computer tomography and pulmonary function of SLE-ILD patients. Rely on the above clinical data to carry out relevant summary and statistical analysis, and explore the correlation between pulmonary function and autoantibodies in SLE-ILD patients, the value of autoantibodies in the diagnosis of SLE-ILD and the independent risk factors of SLE-ILD. Results：SLE-ILD patients have a higher ANA positive rate than SLE-NILD patients. There is no correlation found between pulmonary function indexes and autoantibodies in SLE-ILD patients. The diagnostic sensitivity of ANA for SLE-ILD is 97.8%, specificity only 3.2%. The diagnostic sensitivity and specificity of Ro-52 are 61.8% and 52.9%. Age, ANA, SM, and Ro-52 are independent risk factors for the onset of SLE-ILD.Conclusions: Age, ANA, SM, and Ro-52 are meaningful and notable indicators for SLE patients when in doubt whether they are accompanied by ILD.