Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Bio-guided fractionation and metabolomics reveal antiglioma potential of a Lepidium meyenii fraction enriched in macamides and polyunsaturated fatty acids
View through CrossRef
Lepidium meyenii (maca) is an important food source renowned for its rich profile of bioactive compounds linked to antitumor and antioxidant activities. Herein, bio-guided fractionation and metabolomics were used to investigate L. meyenii potential to produce enriched-fractions with high antiglioma activity. Fractionation was performed by column chromatography using silica gel and Sephadex LH-20 resin as stationary phases, whereas cytotoxicity assays against C6 glioma cells were used as biomarker for the activity of the fractions. UHPLC-Q-TOF-MS/MS and chemometrics were used to assess the chemical profile of the fractions. Fractions F6.5.7 and F6.5.9 were the most potent, reducing C6 cell viability by 99% and 67%, respectively. Chemometrics revealed that these fractions were enriched in macamides and polyunsaturated fatty acids, including 9-oxo-10E,12E-octadecadienoic acid, linolenic acid, and macamide B. These findings highlight the potential of Lepidium meyenii as a functional food source for developing novel antiglioma agents through targeted fractionation of its bioactive compounds.
Title: Bio-guided fractionation and metabolomics reveal antiglioma potential of a Lepidium meyenii fraction enriched in macamides and polyunsaturated fatty acids
Description:
Lepidium meyenii (maca) is an important food source renowned for its rich profile of bioactive compounds linked to antitumor and antioxidant activities.
Herein, bio-guided fractionation and metabolomics were used to investigate L.
meyenii potential to produce enriched-fractions with high antiglioma activity.
Fractionation was performed by column chromatography using silica gel and Sephadex LH-20 resin as stationary phases, whereas cytotoxicity assays against C6 glioma cells were used as biomarker for the activity of the fractions.
UHPLC-Q-TOF-MS/MS and chemometrics were used to assess the chemical profile of the fractions.
Fractions F6.
5.
7 and F6.
5.
9 were the most potent, reducing C6 cell viability by 99% and 67%, respectively.
Chemometrics revealed that these fractions were enriched in macamides and polyunsaturated fatty acids, including 9-oxo-10E,12E-octadecadienoic acid, linolenic acid, and macamide B.
These findings highlight the potential of Lepidium meyenii as a functional food source for developing novel antiglioma agents through targeted fractionation of its bioactive compounds.
Related Results
HIGH OLEIC SUNFLOWER OIL DECREASES ENDOGENOUS BIOSYNTHESIS OF ENERGY FATTY ACIDS AND INCREASES ENDOGENOUS BIOSYNTHESIS OF ω-3 LONG-CHAIN PUFA
HIGH OLEIC SUNFLOWER OIL DECREASES ENDOGENOUS BIOSYNTHESIS OF ENERGY FATTY ACIDS AND INCREASES ENDOGENOUS BIOSYNTHESIS OF ω-3 LONG-CHAIN PUFA
The work shows that Fatty acids of dietary fats provide two main functions in the human and animal body: energy and structural-regulatory, Polyunsaturated fatty acids (PUFA) are th...
Macamides as Potential Therapeutic Agents in Neurological Disorders
Macamides as Potential Therapeutic Agents in Neurological Disorders
Therapeutic treatment of nervous system disorders has represented one of the significant challenges in medicine for the past several decades. Technological and medical advances hav...
Evaluación de la tasa de crecimiento poblacional de Daphnia magna alimentada con harina de Lepidium meyenii (Maca) y harina de Solanum tuberosum (chuño)
Evaluación de la tasa de crecimiento poblacional de Daphnia magna alimentada con harina de Lepidium meyenii (Maca) y harina de Solanum tuberosum (chuño)
Daphnia magna es un crustáceo ampliamente empleado en investigaciones ecológicas, toxicológicas y acuícolas. Su alimentación habitual se basa en microalgas como Chlorella y Sphaero...
Enrichment of Polyunsaturated Fatty Acids from Phyllanthus emblica L. Seed Oil by Urea Inclusion
Enrichment of Polyunsaturated Fatty Acids from Phyllanthus emblica L. Seed Oil by Urea Inclusion
Polyunsaturated fatty acids are essential to human nutrition. Phyllanthus emblica L. seed oil serves as a source of enrichment for the preparation of polyunsaturated fatty acids by...
Plasma Fatty Acid Composition and Incident Ischemic Stroke in Middle-Aged Adults: The Atherosclerosis Risk in Communities (ARIC) Study
Plasma Fatty Acid Composition and Incident Ischemic Stroke in Middle-Aged Adults: The Atherosclerosis Risk in Communities (ARIC) Study
<b><i>Background:</i></b> The association of individual fatty acids with ischemic stroke has not been thoroughly studied, and results have been inconsistent...
Effects on Maternal Macronutrient Intake Towards Human Milk’s Fatty Acids Composition
Effects on Maternal Macronutrient Intake Towards Human Milk’s Fatty Acids Composition
While fatty acids found in human milk account for half of the energy consumed by exclusively breastfed infants, fatty acids such as monounsaturated fatty acids (MUFA) and long chai...
Impact of Portacaval Anastomosis on Plasma Fatty Acid Profile in Cirrhosis: A Randomized 24‐Month Follow‐up Study
Impact of Portacaval Anastomosis on Plasma Fatty Acid Profile in Cirrhosis: A Randomized 24‐Month Follow‐up Study
Background: Portacaval anastomosis has an hypolipemic effect in familial hypercholesterolemia and in healthy animals. In cirrhosis, it raises serum cholesterol, but there is no inf...
Fatty Acids Composition of Basidiocarps of Some Wood Associated Medicinal Mushrooms (Agaricomycetes) from India
Fatty Acids Composition of Basidiocarps of Some Wood Associated Medicinal Mushrooms (Agaricomycetes) from India
In this investigation, crude fat contents and fatty acid compositions of lipids present in the basidiocarps of widely distributed, medicinally important, wild mushrooms (<i>F...