Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Bio-guided fractionation and metabolomics reveal antiglioma potential of a Lepidium meyenii fraction enriched in macamides and polyunsaturated fatty acids
View through CrossRef
Lepidium meyenii (maca) is an important food source renowned for its rich profile of bioactive compounds linked to antitumor and antioxidant activities. Herein, bio-guided fractionation and metabolomics were used to investigate L. meyenii potential to produce enriched-fractions with high antiglioma activity. Fractionation was performed by column chromatography using silica gel and Sephadex LH-20 resin as stationary phases, whereas cytotoxicity assays against C6 glioma cells were used as biomarker for the activity of the fractions. UHPLC-Q-TOF-MS/MS and chemometrics were used to assess the chemical profile of the fractions. Fractions F6.5.7 and F6.5.9 were the most potent, reducing C6 cell viability by 99% and 67%, respectively. Chemometrics revealed that these fractions were enriched in macamides and polyunsaturated fatty acids, including 9-oxo-10E,12E-octadecadienoic acid, linolenic acid, and macamide B. These findings highlight the potential of Lepidium meyenii as a functional food source for developing novel antiglioma agents through targeted fractionation of its bioactive compounds.
Title: Bio-guided fractionation and metabolomics reveal antiglioma potential of a Lepidium meyenii fraction enriched in macamides and polyunsaturated fatty acids
Description:
Lepidium meyenii (maca) is an important food source renowned for its rich profile of bioactive compounds linked to antitumor and antioxidant activities.
Herein, bio-guided fractionation and metabolomics were used to investigate L.
meyenii potential to produce enriched-fractions with high antiglioma activity.
Fractionation was performed by column chromatography using silica gel and Sephadex LH-20 resin as stationary phases, whereas cytotoxicity assays against C6 glioma cells were used as biomarker for the activity of the fractions.
UHPLC-Q-TOF-MS/MS and chemometrics were used to assess the chemical profile of the fractions.
Fractions F6.
5.
7 and F6.
5.
9 were the most potent, reducing C6 cell viability by 99% and 67%, respectively.
Chemometrics revealed that these fractions were enriched in macamides and polyunsaturated fatty acids, including 9-oxo-10E,12E-octadecadienoic acid, linolenic acid, and macamide B.
These findings highlight the potential of Lepidium meyenii as a functional food source for developing novel antiglioma agents through targeted fractionation of its bioactive compounds.
Related Results
Amino Acids, Survey
Amino Acids, Survey
AbstractAmino acids are the main components of proteins. Approximately 20 amino acids are common constituents of proteins and are called protein amino acids, or primary protein ami...
Diversity of fatty acids in different coral species collected in the coastal sea of Nha Trang, Khanh Hoa
Diversity of fatty acids in different coral species collected in the coastal sea of Nha Trang, Khanh Hoa
The total of 15 coral samples belonging to soft coral species Sinularia flexibilis, hard coral Acropora sp., and the hydrocoral Millepora platypylla, were collected in the coastal ...
Amino Acids
Amino Acids
AbstractAmino acids are the main components of proteins. Approximately 20 amino acids are common constituents of proteins and are called protein amino acids, or primary protein ami...
Macamides as Potential Therapeutic Agents in Neurological Disorders
Macamides as Potential Therapeutic Agents in Neurological Disorders
Therapeutic treatment of nervous system disorders has represented one of the significant challenges in medicine for the past several decades. Technological and medical advances hav...
Fatty Acids: Structures and Properties
Fatty Acids: Structures and Properties
AbstractFatty acids are carbon chains with a methyl group at one end of the molecule and a carboxyl group at the other end that are either saturated or unsaturated. They are essent...
Evaluación de la tasa de crecimiento poblacional de Daphnia magna alimentada con harina de Lepidium meyenii (Maca) y harina de Solanum tuberosum (chuño)
Evaluación de la tasa de crecimiento poblacional de Daphnia magna alimentada con harina de Lepidium meyenii (Maca) y harina de Solanum tuberosum (chuño)
Daphnia magna es un crustáceo ampliamente empleado en investigaciones ecológicas, toxicológicas y acuícolas. Su alimentación habitual se basa en microalgas como Chlorella y Sphaero...
Effects of longissimus muscle fatty acid composition in mongolian sheep breeds
Effects of longissimus muscle fatty acid composition in mongolian sheep breeds
This survey to comparative investigates on fat and fatty acid composition in muscles depends on season effects of pastoral and grain fed Mongolian breeds sheep (Mongolian grassland...
HIGH OLEIC SUNFLOWER OIL DECREASES ENDOGENOUS BIOSYNTHESIS OF ENERGY FATTY ACIDS AND INCREASES ENDOGENOUS BIOSYNTHESIS OF ω-3 LONG-CHAIN PUFA
HIGH OLEIC SUNFLOWER OIL DECREASES ENDOGENOUS BIOSYNTHESIS OF ENERGY FATTY ACIDS AND INCREASES ENDOGENOUS BIOSYNTHESIS OF ω-3 LONG-CHAIN PUFA
The work shows that Fatty acids of dietary fats provide two main functions in the human and animal body: energy and structural-regulatory, Polyunsaturated fatty acids (PUFA) are th...