Synthesis of Cyclohex-3-ene(ane)-, 1-Methylcyclohex-3-ene(ane)-, and 5-Alkylphenyl-Substituted Dodecacarboxylic Acids

The article discusses the synthesis of heterocyclic, mono- and dicarboxamide compounds of various structures and functional substitutions based on their electrophilic reactions, using cyclohexane(ene)-, 1-methylcyclohexane(ene)-, 5-phenyl-dodec (as an acylating reagent), acid chlorides of naphthenic and isostructured aliphatic carboxylic acids and various structured aromatic di-, functionally substituted mono- and aliphatic amines (as a substrate).It was shown that for the first time N-cycloacyl derivatives of benzimidazole were obtained by acylation of benzimidazole with cyclohex-3-ene(an)-1-methylcyclohex-3-ene(an)carboxylic acid chlorides. By alkylation and acylation of benzimidazole, its N-alkyl and N-acyl derivatives, as well as C-acyl derivatives of benzimidazole, were obtained based on the acylation reaction of o-phenylenediamine with the corresponding acid chlorides. By hydrogenation of unsaturated cyclohexane-3-ene- and 1-methylcyclohex-3-enecarboxylic acids, the corresponding saturated cyclohexane- and 1-methylcyclohexanecarboxylic acids and their acid chlorides were determined. It has been shown that the direction of the oxidation reaction of amines and the structure of the resulting substances depend on the state of amino groups in the molecule of amino compounds and the nature of other functional groups.