Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Cytotoxic Polyketides from the Marine Sponge-Derived Fungus Pestalotiopsis heterocornis XWS03F09
View through CrossRef
Four new compounds, including two new polyketides, heterocornols M and N (1, 2), and a pair of epimers, heterocornols O and P (3, 4), were isolated from the fermentation broth of the marine sponge-derived fungus Pestalotiopsis heterocornis XWS03F09, together with three known compounds (5–7). The new chemical structures were established on the basis of a spectroscopic analysis, optical rotation, experimental and calculated electronic circular dichroism (ECD). All of the compounds (1–7) were evaluated for their cytotoxic activities, and heterocornols M-P (1–4) exhibited cytotoxicities against four human cancer cell lines with IC50 values of 20.4–94.2 μM.
Title: Cytotoxic Polyketides from the Marine Sponge-Derived Fungus Pestalotiopsis heterocornis XWS03F09
Description:
Four new compounds, including two new polyketides, heterocornols M and N (1, 2), and a pair of epimers, heterocornols O and P (3, 4), were isolated from the fermentation broth of the marine sponge-derived fungus Pestalotiopsis heterocornis XWS03F09, together with three known compounds (5–7).
The new chemical structures were established on the basis of a spectroscopic analysis, optical rotation, experimental and calculated electronic circular dichroism (ECD).
All of the compounds (1–7) were evaluated for their cytotoxic activities, and heterocornols M-P (1–4) exhibited cytotoxicities against four human cancer cell lines with IC50 values of 20.
4–94.
2 μM.
Related Results
Modelling regime shifts of coral reefs to sponge reefs
Modelling regime shifts of coral reefs to sponge reefs
<p>Coral reef ecosystems have been degrading globally for decades due to global climate change and anthropogenic pressure, and corals are expected to continue declining in th...
Trophic interactions of marine sponges
Trophic interactions of marine sponges
<p>Marine communities in the Anthropocene are changing rapidly with potentially severe consequences for ecosystem functioning. Recently, there has been increased interest in ...
Boring Sponges and Bored Oysters – Interactions
between the Bioeroding Sponge Cliona sp. and the New Zealand Flat Oyster Ostrea chilensis
Boring Sponges and Bored Oysters – Interactions
between the Bioeroding Sponge Cliona sp. and the New Zealand Flat Oyster Ostrea chilensis
<p><strong>Bioeroding sponges are the dominant macroborers in many environments. They can affect growth, condition and potentially survival in shellfish populations and...
Sponge city construction and population health
Sponge city construction and population health
IntroductionThis paper focuses on the construction of sponge cities and their effects on population health. Sponge cities in China both solve stormwater problems and are a systemic...
Sponge bioerosion and habitat degradation on Indonesian coral reefs
Sponge bioerosion and habitat degradation on Indonesian coral reefs
<p>Coral reefs are among the most diverse ecosystems on the planet, yet they are also sensitive to anthropogenic disturbances that can degrade these systems. On many degraded...
Research on the dynamic co-evolution of the complex system of economy-innovation-environment of the marine industry in China
Research on the dynamic co-evolution of the complex system of economy-innovation-environment of the marine industry in China
IntroductionIn the context of accelerating the construction of a marine power, relying on scientific and technological innovation to drive the high-quality growth of the marine eco...
Perbandingan Efektivitas Kompres Warm Water Tepid Sponge Dan Plester Demam Terhadap Penurunan Suhu Tubuh Pada Anak Pre-School Dengan Febris Di Puskesmas Tanah Abang Jakarta Tahun 2023
Perbandingan Efektivitas Kompres Warm Water Tepid Sponge Dan Plester Demam Terhadap Penurunan Suhu Tubuh Pada Anak Pre-School Dengan Febris Di Puskesmas Tanah Abang Jakarta Tahun 2023
This research highlights the comparison of the effectiveness of warm water tepid sponge compresses and fever plasters on body temperature in pre-school children with Febris at the ...
Sponge-Associated Amphipod Communities as Bioindicators for Pollution
Sponge-Associated Amphipod Communities as Bioindicators for Pollution
<p>Pollution negatively impacts organisms across all marine ecosystems. Coastal areas are particularly vulnerable to pollution due to their proximity to human settlements. Am...