GLYCYRRHIZA GLABRA FOR ULCER: A BRIEF REVIEW OF ITS THERAPEUTIC POTENTIAL: A NARRATIVE REVIEW

Background: Glycyrrhiza glabra (liquorice) has been widely utilized in traditional and modern medicine for its therapeutic benefits, particularly in gastrointestinal disorders. Its relevance in ulcer management has gained increasing scientific interest due to its diverse pharmacologically active constituents that demonstrate anti-inflammatory, antioxidant, and gastroprotective properties. Understanding its therapeutic potential is essential as peptic and duodenal ulcers remain significant global health concerns. Objective: This narrative review aims to synthesize contemporary evidence on the efficacy, safety, and mechanisms of action of Glycyrrhiza glabra in the prevention and management of gastric and duodenal ulcers. Main Discussion Points: Twenty relevant publications retrieved from Google Scholar, PubMed, and Scopus were analyzed to explore the plant’s pharmacological activities. Key bioactive compounds, particularly flavonoids and glycyrrhizin derivatives, contribute to mucosal protection, enhanced prostaglandin synthesis, and reduction of gastric acid secretion. Preclinical studies consistently indicate ulcer-healing effects through improved mucus production and attenuation of oxidative stress. Early clinical findings suggest symptomatic improvement when used in recommended doses, although variability in formulations and limited human data remain notable challenges. Conclusion: Existing evidence indicates that Glycyrrhiza glabra holds substantial promise as a complementary gastroprotective agent, but further high-quality clinical research is needed to determine optimal dosing, safety thresholds, and standardized formulations for therapeutic use.